231 Human Ecology Building (HEB)
Prof. Chih-Chang (C.C.) Chu received his PhD in chemistry from the Florida State University, USA, and joined Cornell as an assistant professor in Aug. 1978. He is the first recipient of the Rebecca Q. Morgan ’60 endowed chair professor in Jan. 2009 at Cornell University, New York, USA, and retired as the Rebecca Q. Morgan ’60 Professor Emeritus in Jan. 2021. Chu is the recipient of the State University of New York Chancellor’s Award for Excellence in Scholarship and Creative Activities in May, 2009. Chu was inducted into the fellow of International Association of Advanced Materials (IAAM) March 2022, the American Academy of Inventors in 2019, and the College of Fellow of the American Institute of Medical and Biological Engineering in Washington, DC in 2014. Chu received the Golden Eagle award as outstanding alumnus from his alma mater, Tamkang University, Taiwan in 2018. Chu is also the Honorary Professor at the Hong Kong Baptist University since 2019, and the Hong Kong Polytechnic University since 2020. Chu is also the distinguished guest professor of Chang-Chun Institute of Applied Chemistry, Chinese Academy of Science in Chang-Chun, Ji-Lin, and the Xi’An Jiao-Tong University, Xi’An, China. Chu also served on the Scientific Advisory Committee of the Center for Chinese herbal Medicine Drug Development in Hong Kong since 2021, the Biology/Medicine Panel of the Hong Kong Research Grant Council from 2010 - 2013, and was a member of the Hong Kong Research Grant Council Collaborative Research Fund Committee. Prof. Chu is in the editorial board of 7 journals. He has published 221 referred research papers (h-index:65; citation: 13,406), 3 books, a recipient of 85 US and international patents (32 US and 53 International) and 30 pending.
Chu came to Cornell with the mission to establish a multidisciplinary research and teaching programs in biomedical-related field biomaterials and is one of few pioneers in the establishment of Cornell biomedical engineering graduate program in early 1990s and department in 2000s. In second half of 1990s, Prof. Chu has focused on the multidisciplinary research of novel design, synthesis and evaluation of a new novel family of biologic active biodegradable polymers (pseudo-protein biomaterials) that would have very unique biological properties including tunable immune-responsive capability, promoting cell growth, facilitating wound healing and that are nontoxic. The new family of biodegradable pseudo-protein biomaterials created by his program have been engineered or formulated into melt-spun fibers, electron-spun nanofibrous membranes, micro- and nanoparticles as drug carriers for cancer therapy, 3D microporous hydrogels for tissue engineering, 3D printing of tissues/organs like prostate, and films for coating etc. The new family of pseudo-protein biomaterials have been evaluated for surgical repair of injured or diseased tissues, tissue regeneration like vascular grafts, drug-eluting stents, burn treatment, wound closure and drug control/release of both Chinese and western medicines for cancer therapy. A commercial drug-eluting stent (Slender IDS®) with the Chu’s pseudo-protein biomaterial coating was approved for commercial human use in Europe in 2016.
Group Website: http://www.chu.human.cornell.edu/
Prof. C. C. Chu's research activity in the field of advanced materials has focused on the multidisciplinary biomedical polymers for both basic and applied-oriented directions: Applied research involves the design, synthesis of new novel families of biodegradable and biologically active polymers for human body repair, while his Basic research involves the study of degradation mechanisms of synthetic biodegradable polymers, and use of their degradation mechanism as new tools for examining polymer/fiber morphology.
Chu focuses on the research and development of several novel and totally new families of biologically active biodegradable polymers/fibers (i.e., synthetic amino acid-based pseudo-proteins) for tissue regeneration and repair like vascular grafts, wound closure, biodegradable composite orthopaedic devices and drug and gene control/release purposes. These new families of amino acid-based pseudo-protein biomaterials were nature-inspired design of new materials, and have also been engineered into a variety of physical forms (e.g, fibers, fabrics, hydrogels, micro/nanospheres, micelle and film) for a variety of biomedical applications.
The Chu’s latest applied-oriented biomaterial research activity has focused on the design, synthesis and biological property of “Tunable Immuno-responsive (TIR) polymeric biomaterials so that these TIR-biomaterials can be used to alter the phenotype of immune cells like macrophage from cytotoxic inflammatory M1 phenotype to tissue regeneration M2 phenotype or vice versa. The capability of TIR-biomaterials to modulate macrophage phenotype from M1 to M2 was demonstrated in both in vitro and in vivo models for significantly improving the healing rate and quality of a highly inflammatory 3rd degree burn diabetic mouse model. Its application can be extended to treat highly inflammatory diseases like Crohn and inflammatory bowel syndrome etc. The outcome of TIR-biomaterials to modulate macrophage phenotype from M2 to M1 can pave the path toward using TIR-biomaterials for immunotherapy of cancer. These TIR-biomaterials have also been engineered into nanoparticles, fibrous membranes and film forms for potential clinical applications.
In the basic research, Chu focuses on a comprehensive and systematic study of the basic degradation mechanism of synthetic biodegradable polymers and fibers from both theoretical and experimental means for achieving an overall in-depth understanding of biodegradation mechanisms of those commercially viable synthetic biodegradable polymeric biomaterials. In the theoretical front, the Chu’s research activities include: theoretical understanding of the effects of chemical structure on degradation phenomena through supercomputer molecular modeling and molecular dynamic simulations. In the experimental front, Chu examined all possible intrinsic and extrinsic factors that could affect the degradation property and the role of free radicals in degradation. Chu also examined the effect of morphology of synthetic biodegradable polymers and fibers on degradation and the use degradation phenomena to reveal polymer/fiber morphology.
New pseudo-protein-based nano-biomaterials for advanced and better treatment of cancers.
New pseudo-protein biomaterials that can control foreign-body induced immune-response.
Use a multidisciplinary approach and real examples to illustrate how biomaterials could be used in human body reconstruction. The latest research informations from my lab and others are introduced to students. Guest speakers from industry and medical communities may be invited to give students different perceptive of the multidisciplinary integration of the field.
BME 5390: Biomedical materials and devices for human body repair
FSAD 4390: Biomedical Materials and Devices for Human Body Repair
Total 218, Only partial list since 2010 given with h-index 60, Citation 11,535
- Maoli Yin, S. S. Wan, Xuehong Ren, and Chih-Chang Chu, “Development of Inherently Antibacterial, Biodegradable, and Biologically Active Chitosan/Pseudo-Protein Hybrid Hydrogels as Biofunctional Wound Dressings”, ACS Appl. Mater. Interfaces (13), 12, 14688–14699, (2021)
- Hiu Yee Kwan, Qinghua Xu, Ruihong Gong, Zhaoxiang Bian, Chih-Chang Chu, “Targeted Chinese Medicine Delivery by A New Family of Biodegradable Pseudo-Protein Nanoparticles for Treating Triple-Negative Breast Cancer: In Vitro and In Vivo Study”, Frontiers in Oncology, Vol. 10, Article 600298, Jan. (2021), doi: 10.3389/fonc.2020.600298
- Q.H. Xu, and C. C. Chu, “Development of ROS-responsive Amino Acid-based Poly(ester amide) Nanoparticle for Anticancer Drug Delivery”, J. Biomed. Mater. Res. Part A, 109(4): 524-537, (2021)
- Ying Ji, J Li, J. Zhao, S. Shang, C. C. Chu, “A light-facilitated drug delivery system from a pseudo-protein/hyaluronic acid nanocomplex with improved anti-tumor effects”, Nanoscale, 11: 9987 – 10003, (2019).
- C. C. Chu, “A New Multidisciplinary Strategy for Using Novel Tunable Immune Response (TIR) Biomaterial Platform Technology as the New Alternative for Treating Immuno-based Diseases”, LOJ Immunology & Infectious Disease, 25-26, Aug. 28, 2019
- Mingyu He, Luyao Sun, Xiaoling Fu, Sean P. McDonough, Chih-Chang Chu, “Biodegradable amino acid-based poly(ester amine) with tunable immunomodulating properties and their in vitro and in vivo wound healing studies in diabetic rats' wounds”, Acta Biomater. 84: 114-132, (2019).
- J. Zhu, H. Han, FX Li, XL Wang, JY Yu, Chih-Chang Chu, DQ Wu, “Self-assembly of amino acid-based random copolymers for antibacterial application and infection treatment as nanocarriers”, J. Colloid & Interface Sci., 540: 634-646, (2019).
- .B.V. Alapure, Y. Lu, M. He, C. C. Chu, H. Peng, F. Muhale, Y. L. Brewerton, B. A. Bunnell, S. Hong, “Accelerate Healing of Severe Burn Wounds by Mesenchymal Stem Cell Seeded Biodegradable Hydrogel Scaffold Synthesized from Arginine-based Poly(ester amide) and Chitosan”, Stem Cells Dev. 27(23): 1605–1620, (2018)
- Xinru You, Zhipeng Gu, Jun Huang, Yang Kanga, Chih-Chang Chu and Jun Wu, “Arginine based Poly (ester amide) Nanoparticle Platform: From Structure-Property Relationship to Nucleic Acid Delivery”, Acta Biomaterials, 74:180-191, (2018).
- Ying Ji, Shuo Shan, Mingyu He, Chih-Chang Chu, “Inclusion complex from cyclodextrin-grafted hyaluronic acid and pseudo protein as biodegradable nano-delivery vehicle for gambogic acid”, Acta Biomaterialia, 62: 234-245, (2017) (IF 6.319).
- KY Qiu, ZC Zhao, G. Haghiashtiani, SZ Guo, MY He, R Su, ZJie Zhu, DB Bhuiyan, P. Murugan, FB Meng, SH Park, CC Chu, BM Ogle, BR Konety, RM Sweet*, and MC McAlpine*, “3D Printed Organ Models with Physical Properties of Tissue and Integrated Sensors”, Advanced Materials Technology, 3 (3), 1700235, (2017).
- JingLiu, Pei Wang, Chih-Chang Chu, Tingfei Xi, “Arginine-leucine based poly (ester urea urethane) coating for Mg-Zn-Y-Nd alloy in cardiovascular stent applications”, Arginine-leucine based poly (ester urea urethane) coating for Mg-Zn-Y-Nd alloy in cardiovascular stent applications”, Colloids and Surfaces B: Biointerface, 159: 78-88, (2017) (IF 4.152).
- Jing Liu, Pei Wang, Chih-Chang Chu, and Tingfei Xi, “A novel biodegradable and biologically functional arginine-based poly(ester urea urethane) coating for Mg–Zn–Y–Nd alloy: enhancement in corrosion resistance and biocompatibility”, J. Mater Chem, Part B, 5:1787-1802, (2017) (IF 4.543).
- Ke-Mai Pei, Chih-Chang Chu, “Molecular dynamic simulations of a new family of synthetic biodegradable amino acid-based poly(ester amide) biomaterials: Glass transition temperature and adhesion behavior”, Materials Today Chemistry. 4:90-96, (2017).
- C. C. Chu, “Suture Materials” IN: Kirk-Othmer Encyclopedia of Chemical Technology, Wiley and Son, New York, March 2017, DOI: 10.1002/0471238961.1921202112052309.a01.pub3
- Ying Ji, Shuo Shanb Mingyu He, Chih-Chang Chu, “A novel pseudo-protein based biodegradable nano-micellar platform for the delivery of anti-cancer drug: Photo-enhanced micellar structural stability, Unique intracellular trafficking and In vitro therapeutic effect in human colon cancer cells”, Small, 13(1): 1-17, (2017) (IF 8.32)
- Ying Ji, Jihui Zhao, Chih-Chang Chu, “Biodegradable Nanocomplex from Hyaluronic acid and Arginine based Poly(ester amide)s as the Delivery Vehicles for Improved Photodynamic Therapy of Multidrug Resistant Tumor Cells: An In Vitro Study of the Performance of Chlorin e6 Photosensitizer”, J. Biomed. Mater. Res Part A, 105A:1487–1499, (2017) (IF 3.25).
- Mingyu He, Lillian Ro, Jing Liu, Chih-Chang Chu, “Folate Decorated Arginine Based Poly(ester urea urethane) Nanoparticles As Carriers for Gambogic Acid And Effect On Cancer Cells”, J. Biomed. Mater. Res. Part A 105A: 475–490, (2017) (IF3.25)
- Mingyu He, Alicia Potuck, Julie C. Kohn, Katharina Fung, Cynthia A. Reinhart-King, Chih-Chang Chu, “Self-assembled cationic biodegradable nanoparticles from pH-responsive Amino Acid-based Poly(ester urea urethane)s and their application as a drug delivery vehicle”, Biomacromolecules, 17(2): 523-537, (2016) (Impact factor 5.583).
- C. C. Chu, “Novel Synthetic Biodegradable Arginine-Rich Implantable Biomaterials And Devices For Human Body Repair And Reconstruction”, IN: L-Arginine: Structure, Dietary Sources and beneficial Effects, Editor Benjamin L. Soto, Nova Science Publisher, New York, Chapter 4, pp 89-126, (2016).
- Daniel Knecht and C. C. Chu, “A Novel Therapeutic for Diabetic Retinopathy: Mast Cell Stabilizer Impregnated Synthetic Biodegradable Amino Acid-Based Poly(ester amide) Rods”, IN: Biodegradable Polymers, Volume 1: Advancement in Biodegradation Study and Applications”, C. C. Chu (Editor), Nova Science Publisher, New York, Chapter 9, Dec. 2015.
- Janet L. Huie, J. Anastasia Nichols, Julien P. Fey, David Burns, Alicia Potuck and Chih-Chang Chu, “Novel Supercritical Carbon Dioxide Sterilization of Absorbable Sutures and New Amino Acid-based Biomaterials as Suture Coating”, IN: Biodegradable Polymers, Volume 1: Advancement in Biodegradation Study and Applications”, C. C. Chu (Editor), Nova Science Publisher, New York, Chapter 14, Dec. 2015.
- C. C. Chu, “An Overview of A Novel Family of Nature-Inspired Design of Biodegradable Functional Amino Acid-based Poly(ester amide) Biomaterials: New Development, Property and Biomedical Applications”, IN: Biodegradable Polymers, Volume 2: New Biomaterial Advances and Challenges, C. C. Chu (Editor), Nova Science Publisher, New York, Chapter 3, Dec. 2015.
- MingYu He and C. C. Chu, “The New Functional Segmented Urethanes Biomaterials for Biomedical Studies: Design for Biocompatibility, Biodegradability, Self-assembly in Nanoscale”, IN: Biodegradable Polymers, Volume 2: New Biomaterial Advances and Challenges, C. C. Chu (Editor), Nova Science Publisher, New York, Chapter 4, Dec. 2015.
- Yan Zhang, Jinhong Li, Meidong Lang, and Chih-Chang Chu, “Biodegradable Functionalized Aliphatic Polyester: Preparation and Biomedical Application”, IN: Biodegradable Polymers, Volume 2: New Biomaterial Advances and Challenges, C. C. Chu (Editor), Nova Science Publisher, New York, Chapter 9, Dec. 2015.
- De-Qun Wu, Jun Wu, Xiao-Hong Qin and Chih-Chang Chu, “From macro to micro to nano: development of a novel lysine based hydrogel platform and the enzyme triggered self-assembly of macro hydrogel into nanogel”, J. Material Chem. Part B, 3: 2286-2294, (2015).
- Alicia N. Potuck, Beth L. Weed, Cynthia A. Leifer, C.C. Chu, “Electrostatically Self-assembled Biodegradable Microparticles from Pseudo-Proteins and Polysaccharide: Fabrication, Characterization and Biological Properties”, Biomacromolecules, 16(2): 564-577, (2015).
- J. Liu, X.L. Liu, T.F. Xi, C.C. Chu, " A Novel Pseudo-Protein-based Biodegradable Coating for Magnesium Substrate: In vitro corrosion phenomena and cytocompatibility," J. Mater. Chem, Part B 3: 878-893, (2015).
- Karina A. Hernandez, Rachel Campbell Hooper, Tatiana Boyko, Alyssa J. Reiffel Golas, Michel van Harten, D.Q. Wu, Andrew Weinstein, C.C. Chu, Jason A. Spector, “Reduction of Suture Associated Inflammation after 28 days using Novel Biocompatible Pseudo-Protein Poly (ester amide) Biomaterials”, J. Biomed. Mater. Res. Part B Applied Biomaterials,103B:457 - 463, (2015)
- Gunjan Gakhar, Huixian Liu, Roquian Shen, Douglas Scherr, D. Q. Wu, David Nanus and C.C. Chu, “Anti-tumor Effect of Novel Cationic Biomaterials in Prostate Cancer”, Anticancer Research, 34: 3981 – 3990 (2014).
- Xuan Pang, Jun Wu, Chih-Chang Chu and Xuesi Chen, “Synthesis and Characterization of Novel Cationic Hybrid Hydrogels from Pendant Functional Amino Acid-based Poly(ester amide)s”, Acta Biomaterials, 10 (7): 3098-3107, (2014).
- Jun Wu, Xin Zhao, Dequn Wu, Chih-Chang Chu, “Development of a biocompatible and biodegradable hybrid hydrogel platform for sustained release of ionic drugs”, J. Mater. Chem. Part B 2(38): 6660-6668, (2014).
- Mingyu He, Alicia Potuck; Yi Zhang, C. C. Chu, “Arginine based polyester amide / polysaccharide hydrogels and their biological response”, Acta Biomaterial, 10 (6): 2482-2494, (2014).
- Mingyu He and C. C. Chu, “Dual Stimuli Responsive Glycidyl Methacrylate Chitosan-Quaternary Ammonium Hybrid Hydrogel and Its Bovine Serum Albumin Release”, J. Appl. Polym. Sci, 130 (5): 3736-37845, (2013).
- D. Q. Wu, J. Wu, and C. C. Chu, “A novel family of biodegradable hybrid hydrogels from arginine-based poly(ester amide) and hyaluronic acid precursors”, Soft Matter, 9: 3965-3975, (2013)
- Mingyu He and C. C. Chu, “A new family of functional biodegradable Arginine-based polymer urea urethanes: synthesis, characterization and biodegradation”, Polymer, 54: 4112-4125 (2013)
- X. H. Qin, D. Q. Wu, and C. C. Chu, “Dual functions of polyvinyl alcohol (PVA): fabricating particles and electrospinning nanofibers applied in controlled drug release”, J. Nanoparticle Res., 15: 1395 - 1409 (2013)
- Jun Wu and C. C. Chu, “Water insoluble cationic poly (ester amide)s: synthesis, characterization and applications”, J. Mater. Chem. B, 1:353 – 360, (2013)
- C. S. Chen, X. D. Xu, Y. Wang, J. Yang, H. Z. Jia, H. Cheng, C. C. Chu, R. X. Zhuo, X. Z. Zhang, “A peptide nanofibrous indicator for eye-detectable cancer cell identification”, Small, 9 (6): 920-926, (2013)
- C. C. Chu, “Types and Properties of Surgical Sutures", IN: Biotextiles as Medical Implants, B.S. Gupta, M. King and R. Guidoin (eds), Woodhead Publishing Series in Textiles No. 113, Cambridge, England, Part 2 Application, Chapter 10, Oct. 2013, pp 232-274.
- C. C. Chu, ““Materials for Absorbable and Non-absorbable Surgical Sutures”, IN: Biotextiles as Medical Implants, B.S. Gupta, M. King and R. Guidoin (eds), Woodhead Publishing Series in Textiles No. 113, Cambridge, England, Part 2 Application, Chapter 11, Oct. 2013.
- Jun Wu Dequn Wu Martha A. Mutschler, Chih-Chang Chu, “Cationic Hybrid Hydrogels from Amino-Acid-Based Poly(ester amide): Fabrication, Characterization, and Biological Properties”, Advanced Functional Materials, 22 (18): 3815-3823 (2012).
- Jun Wu and Chih-Chang Chu, “Block Copolymer of Poly (ester amide) and Polyesters: Synthesis, Characterization, and in vitro Cellular Response”, Acta Biomaterials, 8 (12): 4314-4323, (2012).
- Jun Wu, Dai Yamanouchi, Bo Liu and C. C. Chu, “Biodegradable Arginine-based Poly(ether ester amide)s as Non-viral DNA delivery Vector and their Structure – Function Study”, J. Mater. Chem. 22: 18983 – 18991, (2012).
- LA Hockaday, KH Kang, NW Colangelo, PYC Cheung, B Duan, E Malone, J Wu, LN Girardi, LJ Bonassar, H Lipson, C. C. Chu and JT Butcher, “Rapdi 3D printing of anatomically accurate and mechanically heterogeneous aortic valve hydrogel scaffolds”, Biofabrication, 4 (3): 1-12, Sept (2012).
- Yuan-Jia Pan, Yuan-Yuan Chen, Dong-Rui Wang, Chuan Wei, Jia Guo, Da-Ru Lu, Chih-Chang Chu, Chang-Chun Wang, “Redox/pH dual stimuli-responsive biodegradable nanohydrogels with varying responses to dithiothreitol and glutathione for controlled drug release”, Biomaterials 33(27): 6570-6579, (2012).
- K. Guo and C. C. Chu, “Synthesis and Characterization of Poly-ε-caprolactone-containing Amino Acid-based Poly(ether ester amide)s”, J. Appl. Polym. Sci. 125(1): 812-819, (2012).
- H. Song and C. C. Chu, “Synthesis and Characterization of A New Family of Cationic Poly(ester amide)s and Their Biological Properties”, J. Appl. Polym. Sci. 124 (5): 3840–3853, (2012).
- Chao Zhong and C. C. Chu, Biomimetic Mineralization of Acid Polysaccharide-based Hydrogels: Towards Porous 3-Dimensional Bone-like Biocomposites”, J. Mater. Chem, 22(13): 6080-6087, (2012)
- H. Xu, J. Wu, C. C. Chu, M. L. Shuler, “Development of disposable PDMS micro cell culture analog devices with photopolymerizable hydrogel encapsulating living cells”, Biomed Microdevices, 14:409-418, (2012).
- C. C. Chu, “Novel Biodegradable Functional Amino Acid-based Poly(ester amide) Biomaterials: Design, Synthesis, Property and Biomedical Applications”, J. Fiber Bioengineering and Informatics” 5(1): 1-31, (2012)
- C. C. Chu, “Biodegradable Polymeric Biomaterials: An Updated Overview”, IN: Biomaterials – Principles and Practices, Ed: Joyce Y. Wong, Joseph D. Bronzino, and Donald R. Peterson, CRC Press, Boca Raton, Fla, Dec. 6, 2012, Chapter 5.
- J. T. Butcher, L. Hockaday, K. Kang, N. Colangelo, J. Wu and C. C. Chu, "High fidelity 3D tissue printing of scalable anatomically accurate living aortic valves," Tissue Engineering Part A 17(3-4), 545 (2011)
- Guoming Sun, C. C. Chu, “Biodegradable Nanospheres Self-Assembled from Complementary Hydrophilic Dextran Macromers”, Carbohydrate Polymers, 86(2): 910-916, (2011).
- E. Chkhaidze, D. Tugushi, D. Kharadze1, Z. Gomurashvili, C. C. Chu, R. Katsarava, “New unsaturated biodegradable poly(ester amide)s composed of fumaric acid, leucine and α,ω-alkylene diols”, J Macromol Sci Part A - Pure & Appl Chem. 48(7): 544 -555, (2011).
- Mingxiao Deng, Jun Wu, Cynthia A. Reinhart-King, and C. C. Chu, “Biodegradable Functional Poly(ester amide)s with Pendant Hydroxyl Functional Groups: Synthesis, Characterization, Fabrication and In Vitro Cellular Response”, Acta Biomaterials 7:1504-1515, (2011).
- Jun Wu, Martha A. Mutschler, C. C. Chu, “Synthesis and Characterization of Ionic Charged Water Soluble Arginine-based Poly (ester amide)”, J. Mater. Sci. Mater in Med. 22:469–479, (2011)
- Joshua A. Horwitz, Katrina M. Shum, Josephine C. Bodle, MingXiao Deng, C. C. Chu, Cynthia A. Reinhart-King, “Biological performance of biodegradable amino acid-based poly(ester amide)s: Endothelial cell adhesion and inflammation in vitro”, J. Biomed. Mater. Res. Part A, 95: 371-380 (2010).
- Huijun Wu, Jintu Fan, C. C. Chu and Jun Wu, “Electrospinning of small diameter 3-D nanofibrous tubular scaffolds with controllable nanofiber orientations for vascular grafts”, J Mater. Sci., Mater. In Med, 21:3207-3215, (2010)
- Chao Zhong and C. C. Chu, On the Origin of Amorphous Cores in Biomimetic CaCO3Spherulites: New Insights into Spherulitic Crystallization”, J. Crystal Growth and Design 10 (12): 5043–5049, (2010).
- Xuan Pang, Jun Wu, Cynthia Reinhart-King, and C. C. Chu, “Synthesis and characterization of functionalized water soluble cationic poly(ester amide)s”, J. Polym. Sci. Part A: Polymer Chemistry, 48: 3758–3766. (2010).
- Chao Zhong,, Jun Wu, C.A. Reinhart-King, C. C. Chu, “Synthesis, characterization and cytotoxicity of photo-crosslinked maleic chitosan-PEGDA hybrid hydrogels”, Acta Biomaterials, 6(10):3908-3918, (2010).
- Xuan Pang and C. C. Chu, “Synthesis, Characterization and Biodegradation of Poly(ester amide)s based Hydrogels”, Polymer, 51: 4200-4210, (2010).
- K. Guo and C. C. Chu, "Synthesis of Biodegradable Amino Acid-based Poly(ester amide) and Poly(ether ester amide) with Pendant Functional Groups", J. Appl. Polym. Sci. 117(6): 3386-3394, (2010).
- Guoming Sun and C. C. Chu, "Impregnation of Tubular Self-Assemblies into Dextran Hydrogels", Langmuir, 26(4): 2831-2838, (2010).
- Xuan Pang and C. C. Chu, "Synthesis, Characterization and Biodegradation of Functionalized Amino Acid-based Poly(ester amide)s", Biomaterials, 31(14): 3745-3754, (2010).
- Guoming Sun and C. C. Chu, "Impregnation of Tubular Self-Assemblies into Dextran Hydrogels", Langmuir, 26(4): 2831-2838, (2010).
Research and teaching in the field of biomaterials and medical devices for human body repair
1978, Postdoc, Chemistry, University of Alabama
1976, Ph.D., Chemistry, Florida State University
1969, B.S., Chemistry, Tamkang University