Chih-Chang Chu


Chih-Chang Chu

Rebecca Q. Morgan '60 Professor
231 Human Ecology Building (HEB)
Phone: (607) 255-1938 Fax: 607-255-1093
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Curriculum Vitae
Biographical Statement:

Detailed information on Professor Chu can be found at

Dr. C.C. Chu, the Rebecca Q. Morgan '60 Chaired Professor,  joined the Cornell faculty in 1978 after completing postdoctoral research on biomaterials for maxillofacial prostheses at the Medical Center of the University of Alabama in Birmingham.  Chu was inducted into the College of Fellow of the American Institute of Medical and Biological Engineering on March 2014, and the receipent of the State University of New York Chancellor’s Award for Excellence in Scholarship and Creative Activities, May, 2009

He had held visiting appointments in the Department of Dental Science at University of Liverpool in the UK, at the National Yang-Ming Medical College in Taiwan, at Hahnemann University School of Medicine in Philadelphia and in the Division of Mechanics and Materials Science, Center for Devices and Radiological Health at the U.S. Food and Drug Administration. He has served on the editorial boards of The Open Macromolecules Journal, The Open Material Science Journal, The Open Biomaterials Journal, J. Fiber Bioengineering and Informatics, and J. Bioengineering and Biomedical Sci.  He also served on the board of directors for the Society of Plastic Engineers (medical plastics division) and was on the editorial board of the Journal of Investigative Surgery. Dr. Chu is also the member of the Biology/Medicine Panel of Hong Kong Grant Research Council. Dr. Chu earned a B.S. in Chemistry from Tamkang University and a Ph.D. in polymer science from Florida State University.

Dr. Chu focuses on the study of biomaterials, particularly the design and synthesis of novel biodegradable polymers/fibers/fabrics for tissue regeneration and repair including vascular grafts, wound closure and drug control/release purposes. This also includes the design and evaluation of novel biologic active biodegradable polymers for surgical repair of injured, diseased or aged tissues, and their impact on wound infection and healing. In basis research, Dr. Chu’s interests include the mechanisms of degradation of biomaterials, theoretical understanding of the effects of chemical structure on degradation through supercomputer molecular modeling, and exploring both intrinsic and extrinsic factors that could affect the degradation properties, such as the role of free radicals in degradation of biomaterials. His research activities also include the synthesis of new biodegradable polymers for immunotherapy of cancer patients, biomaterials for reducing restenosis of vascular stents, novel substrates for cell preservation and tissue engineering, biodegradable vascular grafts, functional wound closure biomaterials for eliminating wound infection during surgery and composite bone cement for orthopaedic surgery.

Dr. Chu has published over 200 research papers and book chapters, a recipient of 64 US and international patents with many pending, an author and editor of 3 books “Wound Closure Biomaterials and Devices”, "Biodegradable Polymers, Vol 1: Advancement in Biodegradation Study and Applications", and "Biodegradable Polymers, Vol 2: New Biomaterial Advances and Challenges". Chu has h-index 52 and citation 8,265 as Dec. 2016.

One of Chu’s new inventions 'Biodegradable, Bioactive, & Programable Hydrogels ' was chosen as a semifinalist for Discover Columbus Foundation Award competition. Dr. Chu has experience working with industry and medical professions to bring his new inventions in biomaterials to clinical reality. Dr. Chu teaches both undergraduate and graduate level courses. One course, “Biomaterials and Medical Devices for Human Body Repair”, nicknamed “Human Spare Parts”, is co-listed with the bioengineering curriculum, and has drawn students from all colleges at Cornell.

Teaching and Advising Statement:

Use a multidisciplinary approach and real examples to illustrate how biomaterials could be used in human body reconstruction.  The latest research informations from my lab and others are introduced to students.  Guest speakers from industry and medical communities may be invited to give students different perceptive of the multidisciplinary integration of the field.

Current Research Activities:

New pseudo-protein-based nano-biomaterials for advanced and better treatment of cancers.

New pseudo-protein biomaterials that can control foreign-body induced immune-response.

New pseudo-protein biomaterials as the coating for biodegradable magnesium-based alloy stents

  • Postdoc 1978 - University of Alabama Chemistry
  • Ph.D. 1976 - Florida State University Chemistry
  • B.S. 1969 - Tamkang University, Taiwan, China Chemistry

Courses Taught:
  • BME 5390 - Biomedical materials and devices for human body repair
  • FSAD 4390 - Biomedical Materials and Devices for Human Body Repair

Related Websites:

Personal Website

Chu's Patents Listed on the Cornell Center for Technology, Enterprise and Commercialization Website

Human Ecology website

Administrative Responsibilities:

Director of Graduate Study

Selected Publications:

 Only those after 2009 are listed here (h-index 48, Citation 7,025):

1.           Daniel Knecht and C. C. Chu, “A Novel Therapeutic for Diabetic Retinopathy: Mast Cell Stabilizer Impregnated Synthetic Biodegradable Amino Acid-Based Poly(ester amide) Rods”,  IN:  Biodegradable Polymers, Volume 1: Advancement in Biodegradation Study and Applications”, C. C. Chu (Editor), Nova Science Publisher, New York, Chapter 9 (In Press).

3.            Janet L. Huie, J. Anastasia Nichols, Julien P. Fey, David Burns, Alicia Potuck and Chih-Chang Chu, “Novel Supercritical Carbon Dioxide Sterilization of Absorbable Sutures and New Amino Acid-based Biomaterials as Suture Coating”, IN: Biodegradable Polymers, Volume 1: Advancement in Biodegradation Study and Applications”, C. C. Chu (Editor), Nova Science Publisher, New York, Chapter 14 (In Press).

4.            C. C. Chu, “An Overview of A Novel Family of Nature-Inspired Design of Biodegradable Functional Amino Acid-based Poly(ester amide) Biomaterials: New Development, Property and Biomedical Applications”, IN: Biodegradable Polymers, Volume 2: New Biomaterial Advances and Challenges C. C. Chu (Editor), Nova Science Publisher, New York, Chapter 3, (In Press).

5.            MingYu He and C. C. Chu, “The New Functional Segmented Urethanes Biomaterials for Biomedical Studies: Design for Biocompatibility, Biodegradability, Self-assembly in Nanoscale”, IN: Biodegradable Polymers, Volume 2: New Biomaterial Advances and Challenges C. C. Chu (Editor), Nova Science Publisher, New York, Chapter 4, (In Press).

6.            Yan Zhang, Jinhong Li, Meidong Lang, and Chih-Chang Chu, “Biodegradable Functionalized Aliphatic Polyester: Preparation and Biomedical Application”, IN: Biodegradable Polymers, Volume 2: New Biomaterial Advances and Challenges C. C. Chu (Editor), Nova Science Publisher, New York, Chapter 9, (In Press).

7.            De-Qun Wu, Jun Wu, Xiao-Hong Qin and Chih-Chang Chu, “From macro to micro to nano: development of a novel lysine based hydrogel platform and the enzyme triggered self-assembly of macro hydrogel into nanogel”, J. Material Chem. Part B, 3: 2286-2294, (2015).

8.            Alicia N. Potuck, Beth L. Weed, Cynthia A.  Leifer, C.C. Chu, “Electrostatically Self-assembled Biodegradable Microparticles from Pseudo-Proteins and Polysaccharide: Fabrication, Characterization and Biological Properties”, Biomacromolecules, 16(2): 564-577, (2015).

9.            J. Liu, X.L. Liu, T.F. Xi, C.C. Chu, " A Novel Pseudo-Protein-based Biodegradable Coating for Magnesium Substrate: In vitro corrosion phenomena and cytocompatibility," J. Mater. Chem, Part B 3: 878-893, (2015).

10.        Karina A. Hernandez, Rachel Campbell Hooper, Tatiana Boyko, Alyssa J. Reiffel Golas,

Michel van Harten, D.Q. Wu, Andrew Weinstein, C.C. Chu, Jason A. Spector, “Reduction of Suture Associated Inflammation after 28 days using Novel Biocompatible Pseudo-Protein Poly (ester amide) Biomaterials”, J. Biomed. Mater. Res. Part B Applied Biomaterials,103B:457 - 463, (2015)

11.        Gunjan Gakhar, Huixian Liu, Roquian Shen, Douglas Scherr, D. Q. Wu, David Nanus and C.C. Chu, “Anti-tumor Effect of Novel Cationic Biomaterials in Prostate Cancer”, Anticancer Research, 34: 3981 – 3990 (2014).

12.        Xuan Pang, Jun Wu, Chih-Chang Chu and Xuesi Chen, “Synthesis and Characterization of Novel Cationic Hybrid Hydrogels from Pendant Functional Amino Acid-based Poly(ester amide)s”, Acta Biomaterials, 10 (7): 3098-3107, (2014).

13.        Jun Wu, Xin Zhao, Dequn Wu, Chih-Chang Chu, “Development of a biocompatible and biodegradable hybrid hydrogel platform for sustained release of ionic drugs”, J. Mater. Chem. Part B 2(38): 6660-6668, (2014).

14.        Mingyu He, Alicia Potuck; Yi Zhang, C. C. Chu, “Arginine based polyester amide / polysaccharide hydrogels and their biological response”, Acta Biomaterial, 10 (6): 2482-2494, (2014).

15.        Mingyu He and C. C. Chu, “Dual Stimuli Responsive Glycidyl Methacrylate Chitosan-Quaternary Ammonium Hybrid Hydrogel and Its Bovine Serum Albumin Release”, J. Appl. Polym. Sci, 130 (5): 3736-37845, (2013).

16.        D. Q. Wu, J. Wu, and C. C. Chu, “A novel family of biodegradable hybrid hydrogels from

arginine-based poly(ester amide) and hyaluronic acid precursors”, Soft Matter, 9: 3965-3975, (2013)

17.        Mingyu He and C. C. Chu, “A new family of functional biodegradable Arginine-based polymer urea urethanes: synthesis, characterization and biodegradation”, Polymer, 54: 4112-4125 (2013)

18.        X. H. Qin, D. Q. Wu, and C. C. Chu, “Dual functions of polyvinyl alcohol (PVA): fabricating particles and electrospinning nanofibers applied in controlled drug release”, J. Nanoparticle Res., 15: 1395 - 1409   (2013)

19.        Jun Wu and C. C. Chu, “Water insoluble cationic poly (ester amide)s: synthesis, characterization and applications”, J. Mater. Chem.  B, 1:353 – 360, (2013)

20.        C. S. Chen, X. D. Xu, Y. Wang, J. Yang, H. Z. Jia, H. Cheng, C. C. Chu, R. X. Zhuo, X. Z. Zhang, “A peptide nanofibrous indicator for eye-detectable cancer cell identification”, Small, 9 (6): 920-926, (2013)

21.        C. C. Chu, “Types and Properties of Surgical Sutures", IN: Biotextiles as Medical Implants, B.S. Gupta, M. King and R. Guidoin (eds), Woodhead Publishing Series in Textiles No. 113, Cambridge, England,  Part 2 Application, Chapter 10, Oct. 2013, pp 232-274.

22.        C. C. Chu, ““Materials for Absorbable and Non-absorbable Surgical Sutures”, IN: Biotextiles as Medical Implants, B.S. Gupta, M. King and R. Guidoin (eds), Woodhead Publishing Series in Textiles No. 113, Cambridge, England,  Part 2 Application, Chapter 11, Oct. 2013.

23.        Jun Wu Dequn Wu Martha A. Mutschler, Chih-Chang Chu, “Cationic Hybrid Hydrogels from Amino-Acid-Based Poly(ester amide): Fabrication, Characterization, and Biological Properties”, Advanced Functional Materials, 22 (18): 3815-3823 (2012).

24.        Jun Wu and Chih-Chang Chu, “Block Copolymer of Poly (ester amide) and Polyesters: Synthesis, Characterization, and in vitro Cellular Response”, Acta Biomaterials, 8 (12): 4314-4323, (2012).

25.        Jun Wu, Dai Yamanouchi, Bo Liu and C. C. Chu, “Biodegradable Arginine-based Poly(ether ester amide)s as Non-viral DNA delivery Vector and their Structure – Function Study”,  J. Mater. Chem. 22: 18983 – 18991, (2012).

26.        LA Hockaday, KH Kang, NW Colangelo, PYC Cheung, B Duan, E Malone, J Wu, LN Girardi, LJ Bonassar, H Lipson, CC Chu and JT Butcher, “Rapdi 3D printing of anatomically accurate and mechanically heterogeneous aortic valve hydrogel scaffolds”, Biofabrication, 4 (3): 1-12, Sept (2012).

27.        Yuan-Jia Pan, Yuan-Yuan Chen, Dong-Rui Wang, Chuan Wei, Jia Guo, Da-Ru Lu, Chih-Chang Chu, Chang-Chun Wang, “Redox/pH dual stimuli-responsive biodegradable nanohydrogels with varying responses to dithiothreitol and glutathione for controlled drug release”, Biomaterials 33(27): 6570-6579, (2012).

28.        K. Guo and C. C. Chu, “Synthesis and Characterization of Poly-ε-caprolactone-containing Amino Acid-based Poly(ether ester amide)s”, J. Appl. Polym. Sci. 125(1): 812-819, (2012).

29.        H. Song and C. C. Chu, “Synthesis and Characterization of A New Family of Cationic Poly(ester amide)s and Their Biological Properties”, J. Appl. Polym. Sci. 124 (5): 3840–3853, (2012).

30.        Chao Zhong and C. C. Chu, Biomimetic Mineralization of Acid Polysaccharide-based Hydrogels: Towards Porous 3-Dimensional Bone-like Biocomposites”, J. Mater. Chem, 22(13): 6080-6087, (2012)

31.        H. Xu, J. Wu, C. C. Chu, M. L. Shuler, “Development of disposable PDMS micro cell culture analog devices with photopolymerizable hydrogel encapsulating living cells”, Biomed Microdevices, 14:409-418, (2012).

32.        C. C. Chu, “Novel Biodegradable Functional Amino Acid-based Poly(ester amide) Biomaterials: Design, Synthesis, Property and Biomedical Applications”, J. Fiber Bioengineering and Informatics” 5(1): 1-31, (2012)

33.        C. C. Chu,  “Biodegradable Polymeric Biomaterials: An Updated Overview”, IN: Biomaterials – Principles and Practices, Ed: Joyce Y. Wong, Joseph D. Bronzino, and Donald R. Peterson, CRC Press,  Boca Raton, Fla, Dec. 6, 2012, Chapter 5.

34.        J. T. Butcher, L. Hockaday, K. Kang, N. Colangelo, J. Wu and C. C. Chu, "High fidelity 3D tissue printing of scalable anatomically accurate living aortic valves," Tissue Engineering Part A 17(3-4), 545 (2011)

35.        Guoming Sun, C. C. Chu, “Biodegradable Nanospheres Self-Assembled from Complementary Hydrophilic Dextran Macromers”, Carbohydrate Polymers, 86(2): 910-916, (2011).

36.        E. Chkhaidze, D. Tugushi, D. Kharadze1, Z. Gomurashvili, C. C. Chu, R. Katsarava, “New unsaturated biodegradable poly(ester amide)s composed of fumaric acid, leucine and α,ω-alkylene diols”, J Macromol Sci Part A - Pure & Appl Chem. 48(7): 544 -555, (2011).

37.        Mingxiao Deng, Jun Wu, Cynthia A. Reinhart-King, and C. C. Chu, “Biodegradable Functional Poly(ester amide)s with Pendant Hydroxyl Functional Groups: Synthesis, Characterization, Fabrication and In Vitro Cellular Response”, Acta Biomaterials 7:1504-1515, (2011).

38.        Jun Wu, Martha A. Mutschler, C. C. Chu, “Synthesis and Characterization of Ionic Charged Water Soluble Arginine-based Poly (ester amide)”, J. Mater. Sci. Mater in Med. 22:469–479, (2011)

39.        Joshua A. Horwitz, Katrina M. Shum, Josephine C. Bodle, MingXiao Deng, C. C. Chu, Cynthia A. Reinhart-King, “Biological performance of biodegradable amino acid-based poly(ester amide)s: Endothelial cell adhesion and inflammation in vitro”, J. Biomed. Mater. Res. Part A, 95: 371-380 (2010).

40.        Huijun Wu, Jintu Fan, C. C. Chu and Jun Wu, “Electrospinning of small diameter 3-D nanofibrous tubular scaffolds with controllable nanofiber orientations for vascular grafts”, J Mater. Sci., Mater. In Med, 21:3207-3215, (2010)

41.        Chao Zhong and C. C. Chu, On the Origin of Amorphous Cores in Biomimetic CaCO3Spherulites: New Insights into Spherulitic Crystallization”, J. Crystal Growth and Design 10 (12): 5043–5049, (2010).

42.        Xuan Pang, Jun Wu, Cynthia Reinhart-King, and C. C. Chu, “Synthesis and characterization of functionalized water soluble cationic poly(ester amide)s”, J. Polym. Sci. Part A: Polymer Chemistry, 48: 3758–3766. (2010).

43.        Chao Zhong,, Jun Wu, C.A. Reinhart-King, C. C. Chu, “Synthesis, characterization and cytotoxicity of photo-crosslinked maleic chitosan-PEGDA hybrid hydrogels”, Acta Biomaterials, 6(10):3908-3918, (2010).

44.        Xuan Pang and C. C. Chu, “Synthesis, Characterization and Biodegradation of Poly(ester amide)s based Hydrogels”, Polymer, 51: 4200-4210, (2010).

45.        K. Guo and C. C. Chu, "Synthesis of Biodegradable Amino Acid-based Poly(ester amide) and Poly(ether ester amide) with Pendant Functional Groups", J. Appl. Polym. Sci. 117(6): 3386-3394, (2010).

46.        Guoming Sun and C. C. Chu, "Impregnation of Tubular Self-Assemblies into Dextran Hydrogels", Langmuir, 26(4): 2831-2838, (2010).  

47.        Xuan Pang and C. C. Chu, "Synthesis, Characterization and Biodegradation of Functionalized Amino Acid-based Poly(ester amide)s", Biomaterials, 31(14): 3745-3754, (2010).

48.        Guoming Sun and C. C. Chu, "Impregnation of Tubular Self-Assemblies into Dextran Hydrogels", Langmuir, 26(4): 2831-2838, (2010). 

Selected Keywords:
Biomaterials, wound healing, fibers, polymers, biodegradable polymers, tissue engineering, material science, nanobiomaterials, nanomedicine, drug delivery vehicles, cancer therapy, stents, sutures, vascular grafts, gene delivery, burn, medical devices, surgery

The information on this bio page is taken from the CHE Annual Report.