228 Savage Hall
Ithaca, New York
Division of Nutritional Sciences


Professor Caudill is internationally recognized for her work on folate and choline, and the intake levels of these nutrients required to promote human health.  She has published over 100 papers, reviews, or chapters in this area, and is frequently an invited speaker on topics related to the importance of choline nutrition during pregnancy and lactation.

Research Program

A primary goal of the Caudill laboratory is to generate data that will inform the development of nutrient intake recommendations that promote mother and child nutrition, health and well-being.  An integrative approach which includes targeted and non-targeted assessments of genomic, epigenetic, biochemical and physiologic endpoints is employed.

Current Research Activities (with graduate students working on the projects in parenthesis and underlined)

Impact of maternal choline intake during pregnancy on DHA delivery to the developing fetus (Kevin Klatt, Siraphat Taesuwan; in collaboration with Dr. Melissa McDougall)

Influence of the gut microbiome on choline bioavailability (Kevin Klatt, Siraphat Taesuwan; in collaboration with Dr. Melissa McDougall, Dr. Devapatla, and Dr. Vidavalur)

Associations between dietary choline intake and blood pressure (Siraphat Taesuwan;in collaboration with Professor Patricia Cassano)

Professor Caudill has 125+ publications including 105 peer reviewed original research papers. A URL to a full list of her published work can be found at  Information can also be obtained at

Papers published in 2017-2018 appear below.

  1. Clara E. Cho, Siraphat Taesuwan, Olga V. Malysheva, Erica Bender, Nathan F. Tulchinsky, Jian Yan, Jessica L. Sutter, Marie A. Caudill. Dietary trimethylamine-N-oxide (TMAO) precursor intake interacts with the gut microbiota to influence TMAO concentrations in healthy young men: a randomized controlled trial. Mol Nutr Food Res. 2017 Jan;61(1).
  2. Clara E. Cho, Marie A. Caudill. Trimethylamine-N-oxide: friend, foe or simply caught in the cross-fire? Trends in Endocrinology & Metabolism. 2017;28: p121–130
  3. Karen E. Christensen, Wenyang Hou, Renata H. Bahous, Liyuan Deng, Olga V. Malysheva, Erland Arning, Teodoro Bottiglieri, Marie A. Caudill, Loydie A. Jerome-Majewska, and Rima Rozen. Moderate folic acid supplementation and MTHFD1-synthetase deficiency in mice, a model for the R653Q variant, result in embryonic defects and abnormal placental development. Am J Clin Nutr. 2016 104(5):1459-1469
  4. Heyjun Park, Patsy M Brannon, Allyson A West, Jian Yan, Xinyin Jiang, Cydne A Perry, Olga V Malysheva, Saurabh Mehta, Marie A Caudill. Maternal vitamin D biomarkers are associated with maternal and fetal bone turnover among pregnant women consuming controlled amounts of vitamin D, calcium, and phosphorus. Bone. 2017 Feb;95:183-191. PMID:27939956
  5. Kevin  Dam Martina Füchtemeier, Tracy  D Farr, Philipp  Boehm-Sturm, Marco Foddis, Ulrich Dirnag, Olga Malysheva, Marie A Caudill, Nafisa Jadavji. Increased homocysteine levels impair reference memory and reduce cortical levels of acetylcholine in a mouse model of vascular cognitive impairment. Behav Brain Res. 2017 Mar 15;321:201-208.
  6. Renata H. Bahous, Nafisa M. Jadavji, Liyuan Deng, Marta Cosín-Tomás, Jessica Lu, Olga Malysheva, Kit-Yi Leung, Ming-Kai Ho, Mercè Pallàs, Perla Kaliman, Nicholas DE Greene, Barry J. Bedell, Marie A. Caudill, Rima Rozen. High dietary folate in pregnant mice leads to pseudo-MTHFR deficiency and altered methyl metabolism, with embryonic growth delay and short-term memory impairment in offspring. Hum Mol Genet 2017;1;26(5):888-900
  7. Diana M. DiMarco, Amanda Missimer, Gabriela Murillo, Bruno S. Lemos, Olga V. Malysheva, Marie A. Caudill, Christopher N. Blesso and Maria Luz Fernandez. Intake of up to 3 Eggs/Day Increases HDL Cholesterol and Plasma Choline While Plasma Trimethylamine?N?oxide is Unchanged in a Healthy Population. Lipids 2017;52(3):255-263.
  8. Ariel B. Ganz , Vanessa V. Cohen, Camille C. Swersky, Julie Stover, Gerardo A. Vitiello, Jessica Lovesky, Jasmine Chuang, Kelsey Shields, Vlad G. Fomin, Yusnier S. Lopez, Sanjay Mohan, Anita Ganti, Bradley Carrier, Olga Malysheva, Marie A. Caudill. Genetic Variation in Choline-Metabolizing Enzymes Alters Choline Metabolism in Young Women Consuming Choline Intakes Meeting Current Recommendations.  Int J Mol Sci. 2017;26;18(2).
  9. Siraphat Taesuwan, Clara E Cho, Olga V Malysheva, Erica Bender, Jian Yan, Anna Thalacker-Mercer, Marie A Caudill. The Metabolic Fate of Isotopically-Labeled Trimethylamine-N-oxide (TMAO) in Humans. J Nutr Biochem. 2017;45:77-82.
  10. Sze Ting (Cecilia) Kwan, Julia King, Jian Yan, Xinyin Jiang, Hallie Klein, Vladislav Fomin, Mark Roberson, Marie Caudill. Maternal choline supplementation during murine pregnancy modulates placental markers of inflammation, apoptosis and vascularization in a fetal sex-dependent manner. Placenta. 2017;53:57-65.
  11. Julia H King, Sze Ting (Cecilia) Kwan, Jian Yan, Kevin C Klatt, Xinyin Jiang, Mark S Roberson, and Marie A Caudill. Maternal choline supplementation alters fetal growth patterns in a mouse model of placental insufficiency. Nutrients 2017;9(7), 765; doi:10.3390/nu9070765
  12. Ariel B. Ganz, Kevin C. Klatt and Marie A. Caudill. Common Genetic Variants Alter Metabolism and Influence Dietary Choline Requirements. Nutrients 2017, 9(8), 837; doi:10.3390/nu9080837
  13. Juha Nam, Esther Greenwald, Chauntelle Jack-Roberts, Tamara Ajeeb, Olga V Malysheva, Marie A Caudill, Martha H Stipanuk, Kathleen Axen, Anjana Saxena, Ekaterina Semernina, Xinyin Jiang. Choline prevents fetal overgrowth and normalizes placental fatty acid and glucose metabolism in a mouse model of maternal obesity. J Nutr Biochem. 2017;12;49:80-88.
  14. Chauntelle Jack-Roberts, Yaelle Joselit, Khatia Nanobashvili, Rachel Bretter, Olga V. Malysheva, Marie A. Caudill, Anjana Saxena, Kathleen Axen, Ahmed Gomaa, Xinyin Jiang. Choline Supplementation Normalizes Fetal Adiposity and Reduces Lipogenic Gene Expression in a Mouse Model of Maternal Obesity. Nutrients. 2017;18;9(8). doi: 10.3390/nu9080899.
  15. Sze Ting (Cecilia) Kwan, Julia H King, Jian Yan, Xinyin Jiang, Jason S Hutzler, Hallie R Klein, Mark S Roberson, Marie A Caudill. Maternal choline supplementation modulates placental nutrient transport and metabolism in late gestation of mouse pregnancy. J. Nutr. 2017 147: 11 2083-2092
  16. Klatt KC, Caudill MA. Pressing the trimethylamine N-oxide narrative. AME Med J 2017;2:132.
  17. Heyjun Park, Patsy M. Brannon, Madeleine Wood, Olga V. Malysheva, Sara Jones, Saurabh Mehta, Marie A. Caudill. Placental vitamin D metabolism and its associations with circulating vitamin D metabolites in pregnant women. Am J Clin Nutr. 2017, Dec;106(6):1439-1448.
  18. Amanda Missimer, Maria Luz Fernandez,  Gregory H. Norris, Diana M. DiMarco, Christopher N. Blesso, Ana Gabriela Murillo, Marcela Vergara-Jimenez, Bruno Lemos, Isabel Medina, Olga V. Malysheva and Marie A Caudill. Compared to an oatmeal breakfast, two eggs per day increased plasma carotenoids and choline without increasing trimethylamine N-oxide concentrations in a healthy population. J Am Coll Nutr. 2018 Feb;37(2):140-148.
  19. Ariel B. Ganz, Heyjun Park, Olga V. Malysheva, and Marie A. Caudill. Vitamin D Binding Protein rs7041 Genotype Alters Vitamin D Metabolism in Pregnant Women. FASEB J.  Published Online:5 Jan 2018
  20. Steven H. Zeisel, Kevin C. Klatt and Marie A. Caudill. Choline. Advances in Nutrition. 2018. In Press

FASEB Summer Conference on Folic Acid, Vitamin B12, and One-Carbon Metabolism.  TMAO: The Good, The Bad, and The Unknown. Session Chair.  August 2018.

Choline Science and Communications Roundtable.  Speaker.  Washington, DC. February 21, 2018

Balchem TMAO Symposium. Fish or Foul. Saint Louis, MO. December 13th & 14th, 2017

Food & Nutrition Conference & Expo (FNCE) What’s New on the Label: Choline, The Nutrient to Know, ADA Annual Meeting.  Chicago, IL. 10/22/2017

Choline Event with Media RDs.  Choline: The Unknown Essential Nutrient. September 27, NYC, NY.

Conceive Baby Choline Webinar.  July 11, 2017.

Choline and Docosahexaenoic Acid: A Synergistic Approach to Improve DHA Delivery to Fetal Tissue?  Scientific Meeting sponsored by Balchem and DSM.  Syracuse, NY. 12/15/2016.

The CHOLINE Information Council, Choline Women’s Health Videoshoot, 6/4/15

Institute of Food Technologists Annual Meeting, "Choline: The Most Important Nutrient Most Overlooked" (ID number 10170), Chicago, IL, July 11-14, 2015.

CME-accredited initiative, “Choline: An Essential Nutrient for Improving Prenatal Development, Pregnancy Outcomes and Ongoing Health. Annenbery Center for Health Sciences at Eisenhower, Faculty Speaker. Towson, Maryland. March 12, 2014.





Impact and Outcomes (Examples) Research featured in the Cornell Chronicle. Adequate choline in pregnancy may have cognitive benefits for offspring. January 2018. Also see: Choline Event with the Media. Shining the Light on Choline. New York, NY. Sept 27, 2017. Conceive Baby Seminar. Importance of Choline Preconception. The podcast version is on the Conceive Baby Podcast Series page as well as on iTunes. 7/12/2017 The Washington Post. The nutrient you didn’t know you were missing by Christy Brissette. 12/9/2016 The CHOLINE Information Council, Choline Women’s Health Videoshoot, 6/4/15 Interview with Kim Conte "Are You Getting Enough Choline?", July 28 2015 Choline- Moms Everyday TV show, July 29 2015 ESCONDIDO, Calif., July 28, 2015 /PRNewswire/ Research Shows Choline Plays Critical Role in Pregnancy and Women's Health. Huffington Post. Choline Consumption During Pregnancy May Lower Babies’ Risk Of Diabetes: Study.

I have taught the popular upper division Nutrition and Disease Course (NS 4410) for the past 10 years. As of Spring 2019, I will transition to Human Nutrition and Nutrient Metabolism (NS 3310). A top priority for me in my teaching and advising is to convey respect for the students and a sense that I care about their learning.

NS 4410  - Nutrition and Disease  (4 credit units). This course combines the principles of nutrition, biochemistry, physiology, genetics, pharmacology, and pathology to understand disease risk, prevention, progression and management. The course is organized in a lecture format with opportunities for the class to engage in the discussion of original research articles  of high current interest in the area of nutrition and health, case-studies and thinking critically activities.

Education: BA, 1990, Physical Education (Summa Cum Laude), College of Education, University of North Florida, Jacksonville, FL; BS, 1992, Health Science (Summa Cum Laude), College of Health, University of North Florida, Jacksonville, FL; MS, 1993, Health Science, College of Health, University of North Florida, Jacksonville, FL; PhD, 1997, Nutritional Sciences, Food Science and Human Nutrition, College of Agriculture, University of Florida, Gainesville, FL (Lynn Bailey, Thesis Advisor); Additional Training Registered Dietitian, 1994, Dietetic Internship at Emory University Hospital, Atlanta, GA.

University Committees HE Representation on the University Tenure Appeals Panel, July 1 2017-June 30 2022 Stephen H. Weiss Fellows Selection Committee, July 1, 2016-June 30, 2019 (Chair in 2018) Research Council, 2001-2007 (Chair in 2005-2007; Cal Poly Pomona University) Institutional Review Board for Human Subject Use, 2004-2007, Cal Poly Pomona Honors Program Advisory Committee, 2002-2004, Cal Poly Pomona College Committees Biology Curriculum, DNS Representative, 2017-2020, Cornell University CALS Curriculum, DNS Representative. 2017-2020, Cornell University CALS Strategic Planning Coordinating Committee, Member, 2013-2014, Cornell University Ad-hoc Tenure Committee, Member, 2012, 2018 CALS. Cornell University Outcomes Assessment Committee, Chair, 1998-2000, Cal Poly Pomona University Department Committees Curriculum Committee, Chair, 2017-2020, Cornell University Faculty Search Committee, Chair, Assistant Professor in Biochemistry, Metabolism and Genomics. DNS. April 1 2017-Present, Cornell University Maternal and Child Nutrition (MCN) Training Grant Executive Committee. 2016-present Faculty Mentoring Committee (n=1); 2013-Present. Appointments and Tenure Committee, Member, DNS, September 2013-August 2016 Teaching & Research Fellow Search Committee Meeting, Member, DNS, 2011-Present Post-baccalaureate Program in Health Studies Admission Committee, Member, DNS, 2010-2016 Nurse Practitioner Search Committee, Member, DNS, 2012-2013 Faculty Search Committee, Chair, Human Metabolism, DNS, 2011-2012 Graduate Admissions Committee, DNS, 2011-2013 Human Metabolic Research Unit (HMRU) Advisory Committee, DNS, Cornell University, 2007-Present Graduate Admissions Committee, DNS, 2008-2010 Faculty Search Committee, Human Metabolism, DNS, 2008-2009 Faculty Search Committee, Member, Food Scientist, Cal Poly Pomona, 2004-2005 Faculty Search Committee, Member, Food Scientist, Cal Poly Pomona, 2003-2004 Retention, Tenure and Promotion Committee, Cal Poly Pomona, 2003-2004 Coordinator of the Outcomes Assessment section of the departmental self study, Cal Poly Pomona, 2001-2002 Outcomes Assessment Committee, Chair, Cal Poly Pomona, 1999-2001
Conceive Baby Seminar. Importance of Choline Preconception. The podcast version is on the Conceive Baby Podcast Series page as well as on iTunes. 7/12/2017 The CHOLINE Information Council, Choline Women’s Health Videoshoot, 6/4/15