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Kimberly

O'Brien

Professor
230 Savage Hall
Ithaca, New York
Division of Nutritional Sciences

Biography

Kimberly O’Brien received her B.S. in Biology from the University of New Hampshire and her PhD in Nutrition from the University of Connecticut, Storrs. Her professional training included fellowships with the National Institute of Child Health and Human Development, Laboratory of Theoretical and Physical Biology/Section for Metabolic Analysis and Mass Spectrometry and the Children’s Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine. Professor O'Brien joined the faculty in the Division of Nutritional Sciences after working for 10 years as a faculty member in the Center of Human Nutrition at Johns Hopkins Bloomberg School of Public Health.

Professor O’Brien’s research has centered on studies designed to better understand mineral metabolism and bone health in infants, children, and pregnant and lactating women in both developed and developing countries. To address issues of calcium metabolism, she has undertaken metabolic studies in groups including children from osteoporotic families, pregnant and lactating adolescents, and children with chronic diseases such as cystic fibrosis and HIV infection. Her current research focuses on the impact of adolescent pregnancy, particularly among minority populations, on maternal and fetal bone health, risk of anemia, and maternal and neonatal vitamin D and iron physiology.  Partitioning of nutrients between the mother and fetus is addressed at the cellular level by assessing placental mineral transporters in relation to maternal and neonatal status.

To allow for kinetic studies of human mineral metabolism, a mass spectrometry laboratory has been added to the existing resources in the Human Metabolic Research Unit. This laboratory includes instrumentation for high-sensitivity mineral stable isotope analysis using a  Triton TI magnetic sector thermal ionization mass spectrometer. This laboratory also provides analytical services through collaboration with other academic institutions in the country.

Calcium Metabolism and Bone Health; Maternal and Neonatal Anemia, Control of Maternal/Fetal Nutrient; Partitioning and Placental Mineral Transport;  Vitamin D Kinetics during Pregnancy, Erythroferrone concentrations in maternal-neonatal dyads

Güngör D, Nadaud P, LaPergola CC, Dreibelbis C, Wong YP, Terry N, Abrams SA, Beker L, Jacobovits T, Järvinen KM, Laurie A. Nommsen-Rivers L, O’Brien KO, Oken E, Pérez-Escamilla R, Ziegler RE, Spahn JM (USDA Pregnancy/Birth-24 months Technical Expert Committee 1). Infant milk-feeding practices and food allergies, allergic rhinitis, atopic dermatitis, and asthma throughout the lifespan: A systematic review. Am J Clin Nutr (Special Supplement), 2018, In Press.

Güngör D, Nadaud P, Dreibelbis C, LaPergola CC, Wong YP, Terry N, Abrams SA, Beker L, Jacobovits T, Järvinen KM, Laurie A. Nommsen-Rivers L, O’Brien KO, Oken E, Pérez-Escamilla R, Ziegler RE, Spahn JM (USDA Pregnancy/Birth-24 months Technical Expert Committee 1). Infant milk-feeding practices and childhood leukemia: A systematic review. Am J Clin Nutr (Special Supplement), 2018, In Press.

Güngör D, Nadaud P, LaPergola CC, Dreibelbis C, Wong YP, Terry N, Abrams SA, Beker L, Jacobovits T, Järvinen KM, Laurie A. Nommsen-Rivers L, O’Brien KO, Oken E, Pérez-Escamilla R, Ziegler RE, Spahn JM (USDA Pregnancy/Birth-24 months Technical Expert Committee 1). Infant milk-feeding practices and celiac disease and irritable bowel disease and outcomes in offspring: A systematic review. Am J Clin Nutr (Special Supplement), 2018, In Press.

Güngör D, Nadaud P, LaPergola CC, Dreibelbis C, Wong YP, Terry N, Abrams SA, Beker L, Jacobovits T, Järvinen KM, Laurie A. Nommsen-Rivers L, O’Brien KO, Oken E, Pérez-Escamilla R, Ziegler RE, Spahn JM (USDA Pregnancy/Birth-24 months Technical Expert Committee 1). Infant milk-feeding practices and diabetes outcomes in offspring: A systematic review. Am J Clin Nutr (Special Supplement), 2018, In Press.

Güngör D, Nadaud P, LaPergola CC, Dreibelbis C, Wong YP, Terry N, Abrams SA, Beker L, Jacobovits T, Järvinen KM, Laurie A. Nommsen-Rivers L, O’Brien KO, Oken E, Pérez-Escamilla R, Ziegler RE, Spahn JM (USDA Pregnancy/Birth-24 months Technical Expert Committee 1). Infant milk-feeding practices and cardiovascular disease outcomes in offspring: A systematic review. Am J Clin Nutr (Special Supplement), 2018, In Press. 

Delaney KM, Guillet R, Fleming RE, Yu R, Pressman EK, Vermeylen F, Nemeth E, O’Brien KO. Umbilical Cord Serum Ferritin Concentrations: Relation to Markers of Iron status and Erythropoiesis. In Press; J Nutr; 2018.

Best CM, Pressman EK, Queenan RA, Cooper E, O’Brien KO. Longitudinal changes in serum vitamin D binding protein and free 25-hydroxyvitamin D concentrations in a multiracial cohort of pregnant adolescents. J Steroid Chem and Molec Biol; 2018; ep 29. pii: S0960-0760(18)30364-9. doi: 10.1016/j.jsbmb.2018.09.019. [Epub ahead of print]

Steinl G, Whisner CM, Pressman EK, Cooper E, Groth SW, O’Brien KO. Patterns and correlates of self-reported physical activity in a cohort of racially diverse pregnant adolescents. J Pediatr Adoles Gynecology 2018; Sep 14. pii: S1083-3188(18)30307-3. doi: 10.1016/j.jpag.2018.09.003. [Epub ahead of print]

O’Brien KO, Abrams SA. Using stable isotope tracers to study bone metabolism in children. J Physiology Invited Review. J Physiol. 2018 Jun 5. doi: 10.1113/JP275452. [Epub ahead of print]

Ru Y, Pressman EK, Cooper B, Guillet R, Katzman PJ, O’Brien KO. Umbilical cord hepcidin concentrations are associated with the variance in iron status among multiple birth neonates. J Nutr 2018; 148:1-7.

Best CM, Pressman EK, Queenan RA, Cooper E, Vermeylen F, O’Brien KO. Gestational age and maternal serum 25-hydroxyvitamin D concentration interact to affect 24,25-dihydroxyvitamin D concentration in pregnant adolescents. J Nutr 2018; Jun 1;148(6):868-875.

Ru Y, Pressman EK, Cooper B, Guillet R, Katzman PJ, O’Brien KO. Predictors of Anemia and iron status at birth in neonates born to women carrying multiple fetuses. Pediatric Research 2018; Aug 84(2):199-204.

Reddy MB, Armah SM, O’Brien KO, Chen D. Iron Absorption from iron-enriched aspergillus oryzae is similar to ferrous sulfate in healthy female subjects. Current Developments in Nutrition 2018; Jan 29; 2(3):nyz004. Doi: 10.1093/cdn/nyz004. eCollection 2018 Mar.

Steinl G, Durlacher J, Katzman PJ, Ru Y, Guillet R, Pressman E, Cooper E, O’Brien KO. Umbilical Cord Coiling in High-Risk Pregnancies: Associations with Determinants of Adverse Birth Outcomes and Iron Status. Pediatric and Developmental Pathology 2018; Nov-Dec; 21(6):537-47.

Weber D, O’Brien KO, Schwartz GJ. Evidence of disordered calcium metabolism in adolescent girls with type 1 diabetes: an observational study using a dual-stable calcium isotope technique. Bone 2017; 105:184-90. 10.1016/j.bone.2017.09.001

O’Brien KO, Ru Y. Iron Status of North American Pregnant Women: Other Evidence from the United States and Canada. Am J Clin Nutr 2017; Oct 25 doi:10.3945/ajcn.117.155747

de Angelis P, Miller RK, Darrah TH, Katzman PJ, Kent T, O’Brien KO. Elemental content of the placenta: A comparison between two high-risk obstetrical populations, adult women carrying multiples and adolescents carrying singletons. Environmental Research 2017; Jul 14;158:553-565. doi: 10.1016/j.envres.2017.07.008

Akoh CC, Pressman EK, Whisner C, Thomas C, Cao C, Kent T, Cooper E, O’Brien KO. Vitamin D Mediates the Relationship between Placental Cathelicidin and group B streptococcus Colonization during Pregnancy. J Reprod Immunol. 2017 Jun;121:42-48. doi: 10.1016/j.jri.2017.06.001.

Akoh CC, Pressman E, Cooper E, Queenan R, Pillittere J, O’Brien KO. Vitamin D is Associated with Infections and Proinflammatory Cytokines During Pregnancy. Reprod Sci. 2017 Jan 1:1933719117715124. doi: 10.1177/1933719117715124

Akoh C, Pressman EK, Cooper E, Queenan RA, Pillittere J, O’Brien KO. Prevalence and Risk Factors for Infections in a Pregnant Adolescent Population. J Pediatr Adoles Gynecology; 2017 Feb;30(1):71-5.

Adjunct Professor, University of Rochester School of Medicine and Dentistry, Department of Obstetrics and Gynecology, Rochester, NY

I am a member of the USDA/DHHS Technical Expert Committee Working Group 1 for the Birth to 24 Months Project: As part of this group of scientists our goal is to evaluate the evidence base to support the inclusion of infants and children from birth to 24 months of age in the Dietary Guidelines for Americans. Findings from this working group will be published in topic specific manuscripts in The American Journal of Clinical Nutrition.

I am a permanent member of the NIH Integrative Nutrition and Metabolic Processes (INMP) Study Section.


In collaboration with physicians at the UofR and with current doctoral students, we have co-authored on-line continuing education articles for obstetrical and medical and health professionals for the Peri-FACTS® Academy. This is an online continuing education program that allows OB/GYN health care providers earn nursing contact hours and CME credits any time, from any computer; www.peri-facts.urmc.edu

 

I teach a one-semester undergraduate Human Anatomy and Physiology course and co-teach a graduate course on micronutrient metabolism. I am committed to promoting hands-on, investigative, opportunities for undergraduate and graduate students interested in clinical research. Our laboratory group actively involves undergraduates; many of whom are authors on the research generated. Scientific writing is emphasized and facilitated with weekly undergraduate and graduate writing groups and with weekly meetings for all on-site and off-site study personnel.  Graduate and post-doctoral students gain mentoring experience by providing guidance in methods development and data analysis to undergraduate laboratory students.

NS3410 - Human Anatomy and Physiology
NS6310 - Micronutrients (Primary Instructor Charles McCormick)

NS6190 - Field of Nutrition Seminar

NS4010 - Independent Study

BIOG 4990 - Independent Study

NRSA Fellowship 1993-1995 - Baylor College of Medicine, Children's Nutrition Research Center, Houston, TX

IRTA Fellowship - 1991-1993 - National Institutes of Health, Section on Metabolic Analysis and Mass Spectrometry, Bethesda, MD

PhD - 1991     University of Connecticut, Nutrition

BS   - 1985     University of New Hampshire, Biology