Chromatin in the nucleus of cells consists of the DNA, and proteins intimately associated with the DNA. The proteins are primarily histones that are assembled into nucleosomes.  Both the DNA and histones are chemically modified, and nucleosome positioning is highly regulated. Collectively, these modifications, and nucleosome location define the chromatin state of a cell.  Chromatin states are fundamentally important to cell identity, and their gene expression patterns. Those states change with different environmental conditions, during aging, and with disease; and they affect overall cellular, tissue, and organismal traits. How these changes occur, and influence health is of major interest to the lab.

Methods for querying chromatin state are rapidly changing, and include single cell analyses, which enable parallel measurements in large numbers of individual cells.  Single cell methods provide very different information than ensemble methods that use populations of cells collected from tissues. They are particularly useful for complex tissues, like brain, where changes in chromatin state, or abundances of a subset of cells, are important for complex phenotypes. These changes in state or abundance can escape detection when ensemble assays are used, but can be captured by single cell analyses.

The lab is applying single cell methods to brains and other tissues to characterize mouse models whose genetic or nutritional manipulations impart phenotypes relevant to human health and disease; we also apply them to human disease specimens. Our goal is to understand better the cellular and genomic changes, and ultimately the mechanisms, underlying physiologically important traits. 

Dr. Soloway's CV

Paul Soloway
Cornell University
T4-018 Veterinary Research Tower
Ithaca, NY 14853
soloway@cornell.edu

Please visit the PubMed website for a list of publications.

Current Members

Seoyeon Lee, Nutrition Graduate Student
Roman Spektor, Genomics & Development Graduate Student

Doctoral, Post Doctoral, Visiting Scientist Alumni

Dr. Erin Chu
Dr. Nadia Drake
Dr. Jonathan Flax
Dr. James Hagarman
Dr. Herry Herman
Dr. Rebecca Homes
Dr. Byung-Ryool Hyun
Dr. Krista Kauppinen
Dr. Marie Lee
Dr. Anders Lindroth
Dr. Chelsea McLean
Dr. Yoon Jung Park
Dr. David Taylor
Dr. Zhiping Wang
Dr. Bongjune Yoon
Dr. Ruqian Zhao

Masters Alumni

Keith Osiewicz
Dr. Calphor Carty
Michael Lu
Dr. Megan Eaton Gervasi
Aimee Sikora Stablewski

Undergraduate Research Assistant Alumni

Dr. Adebusola Alagbala
Dr. Jenna Bernstein
David Chiu
Dr. Gregoriy Dokshin
Dr. Maxine Fields
Laura Kerepesi
Oliver Gregory
Crystal Han
Leah Hellerstein
Margaret Hofstedt
Benjamin Hu
Jesse Huang
Sabrina Imam
Amy Jobe
ChanYang Ju
Dr. Neha Kumar
Joshua Mervis
Claudia Mimoso
Dr. Jessica Piel
Ashley Radpavar
Dr. Aditya Shirali
Dariana Soto-Reyes
Kingsley Weaver
Dr. Jerry Wei
Liana Wong
Warren Wu

If you are interested in post-doctoral studies, or are a Cornell graduate or undergraduate student seeking research opportunities, please email Dr. Soloway.