Mitchell SB., Hung YH., Thorn TL., Zou J., Baser F., Gulec S., Cheung C., Aydemir TB.* Sucrose-induced hyperglycemia dysregulates intestinal zinc metabolism and integrity. Volume 10 – 2023. doi: 10.3389/fnut.2023.1220533

In revision:

Thorn TL, Mitchell SB, Kim Y,  Lee MT, Comrie JMC, Johnson EL, Aydemir TB.*  Metal transporter SLC39A14/ZIP14 modulates regulation between the gut microbiome and host metabolism.

Hung YH., Kim Y., Thorn TL., Mitchell SB., Aydemir TB.* Absence of Slc39a14/Zip14 in mouse pancreatic beta cells results in hyperinsulinemia and exacerbation of diet-induced metabolic dysfunction.


Sun T., Wang K., Wyman B., Sudibyo H., Liu G., Beal C., Manning S., Johnson ZI., Aydemir TB., Tester JW., Lei XG. Supplemental dietary full-fatted and defatted Desmodesmus sp. exerted similar effects on growth performance, gut health, and excreta hydrothermal liquefaction of broiler chicks. Algal Research. 2021 54(2021);102205, ISSN 2211-9264, https://doi.org/10.1016/j.algal.2021.102205.


Aydemir, TB., Thorn, TL., Ruggiero, C., Pompilus, M., Febo, M. and Cousins RJ. 2020. Intestine-specific deletion of metal transporter Zip14 (Slc39a14) causes brain manganese overload and locomotor defects of manganism. Am J Physiol Gastrointest Liver Physiol. 

Lin, M., Colon-Perez, L., Sambo, D., Miller, D., Lebowitz, J., Jimenez-Rondan, F., Cousins, RJ., Horenstein, N., Aydemir, TB., Febo, M. and Khoshbouei, H. 2020. Mechanism of manganese dysregulation of dopamine neuronal activity. J Neurosci. 

Kim, J., Aydemir, TB., Jimenez-Rondan, F., Ruggiero, C., Kim, MH. and Cousins RJ. 2020. Deletion of metal transporter Zip14 (Slc39a14) produces skeletal muscle wasting, endotoxemia, Mef2c activation and induction of miR-675 and Hspb7. Scientific Reports.

Gheller ME., Vermeylen F., Handzlik MK., Gheller BJ., Bender E., Metallo C., Aydemir TB., Smriga M., Thalacker-Mercer AE. Tolerance to graded dosages of histidine supplementation in healthy human adults. Am J Clin Nutr. 2020 Nov 11;112(5):1358-1367. doi: 10.1093/ajcn/nqaa210. PubMed PMID: 32766885.


Hendrickx, G., Borra, V. M., Steenackers, E., Yorgan, T. A., Hermans, C., Boudin, E., Waterval, JJ., Jansen, IDC., Aydemir, TB., … Van Hul, W. 2018. Conditional mouse models support the role of SLC39A14 (ZIP14) in Hyperostosis Cranialis Interna and in bone homeostasis. PLOS Genetics, 14(4), e1007321.


Kim MH., Aydemir TB., Kim J., Cousins RJ. 2017. Hepatic ZIP14-mediated zinc transport is required for adaptation to endoplasmic reticulum stress. Proc Natl Acad Sci U S A, 114:E5805–14. PMC5530682

Aydemir TB., Kim MH., Kim J., Colon-Perez LM., Banan G., Mareci TH., Febo M., Cousins RJ. 2017. Metal transporter ZIP14 (SLC39A14) deletion in mice increases manganese deposition and produces neurotoxic signatures and diminished motor activity. J Neurosci, 37:5996–6006. PMC5481939


Aydemir TB., Troche C., Kim MH., Cousins RJ. 2016. Hepatic ZIP14-mediated zinc transport contributes to endosomal insulin receptor trafficking and glucose metabolism. J Biol Chem, 291:23939–51. PMCID: PMC5104920

Aydemir TB., Troche C., Kim J., Kim MH., Teran OY., Leeuwenburgh C., Cousins RJ. 2016. Aging amplifies multiple phenotypic defects in mice with zinc transporter Zip14 (Slc39a14) deletion. Exp Gerontol, 85:88–94. PMCID: PMC5101137

Kim MH., Aydemir TB., Cousins RJ. 2016. Dietary zinc regulates apoptosis through the p-elF2α/ATF4/CHOP pathway during pharmacologically induced endoplasmic reticulum stress in livers of mice. J Nutr, 146:2180–6. PMCID: PMC5086795

Troche C., Aydemir TB., Cousins RJ. 2016. Zinc transporter Slc39a14 regulates inflammatory signaling associated with hypertrophic adiposity. Am J Physiol Endocrinol Metab, 310(4): E258–68. PMCID: PMC4971811


Guthrie GJ., Aydemir TB., Troche C., Martin AB., Chang SM., Cousins RJ. 2015. Influence of ZIP14 (slc39A14) on intestinal zinc processing and barrier function. Am J Physiol Gastrointest Liver Physiol, 308(3): G171–8. PMCID: PMC4312952


Martin AB., Aydemir TB., Guthrie GJ., Samuelson DA., Chang SM., Cousins RJ. 2013. Gastric and colonic zinc transporter ZIP11 (Slc39a11) in mice responds to dietary zinc and exhibits nuclear localization. J Nutr, 143(12):1882-8. PMCID: PMC3827636


Aydemir TB., Chang SM., Guthrie GJ., Maki AB., Ryu MS., Cousins RJ. 2012 Zinc transporter ZIP14 functions in hepatic zinc, iron and glucose homeostasis during the innate immune response (endotoxemia). PLoS One, 7(10): e48679. doi:10.1371/journal.pone. PMCID: PMC3480510

Aydemir TB., Sitren HS., Cousins RJ. 2012. The zinc transporter Zip14 influences c-Met phosphorylation and hepatocyte proliferation during liver regeneration in mice. Gastroenterology, 142:1536–46. PMCID: PMC3635537

Ryu MS., Guthrie GJ., Maki AB, Aydemir TB, Cousins RJ. 2012. Proteomic analysis shows the up-regulation of erythrocyte dematin in zinc-restricted human subjects. Am J Clin Nutr, 95:1096–102. PMCID: PMC3325834


Aydemir TB., Liuzzi JP., McClellan S., Cousins RJ. Zinc transporter ZIP8 (SLC39A8) and zinc influence IFN-gamma expression in activated human T cells. J Leukoc Biol. 2009 Aug;86(2):337-48. doi: 10.1189/jlb.1208759. Epub 2009 Apr 28. PubMed PMID: 19401385; PubMed Central PMCID: PMC2726764.


Aydemir TB., Blanchard RK., Cousins RJ. Zinc supplementation of young men alters metallothionein, zinc transporter, and cytokine gene expression in leukocyte populations. Proc Natl Acad Sci U S A. 2006 Feb 7;103(6):1699-704. doi: 10.1073/pnas.0510407103. Epub 2006 Jan 24. PubMed PMID: 16434472; PubMed Central PMCID: PMC1413653.