The Lujan Laboratory investigates the link between nutrition, metabolism and reproductive physiology in women. Specific interests include elucidating the pathophysiological mechanisms that to lead amenorrhea (loss of regular menstrual cycles) in women, as well as improving the diagnosis, evaluation, and treatment of polycystic ovary syndrome (PCOS) across the reproductive lifespan -- a condition of impaired fertility that is tightly linked to insulin resistance and excess male hormone production.

RESEARCH
The Lujan Laboratory uses high-resolution serial ovarian ultrasonography to track changes in follicle development and to identify key periods during the menstrual cycle in which follicle development and ovulation are most sensitive to metabolic cues (e.g. energy balance, body composition, fat-derived hormones, glucose, insulin, and androgens). Qualitative approaches are also incorporated in our research to further understanding of current lifestyle behaviors, beliefs, and experiences in women with amenorrhea. By examining the physiological and emotional health associated with amenorrhea, the goal of the Lujan Laboratory is to develop nutritional, lifestyle and pharmaceutical regimens that promote and preserve reproductive health in women.