Rebecca Q. Morgan '60 Professor
231 Human Ecology Building (HEB)
Ithaca, New York
Fiber Science & Apparel Design

New pseudo-protein-based nano-biomaterials for advanced and better treatment of cancers.

New pseudo-protein biomaterials that can control foreign-body induced immune-response.

Total 212, Only partial list since 2010 given with h-index 56, Citation 10,214 as Dec 2017

  1. Ying Ji, Shuo Shan, Mingyu He, Chih-Chang Chu, “Inclusion complex from cyclodextrin-grafted hyaluronic acid and pseudo protein as biodegradable nano-delivery vehicle for gambogic acid”, Acta Biomaterialia, 62: 234-245, (2017) (IF 6.319).
  2. KY Qiu, ZC Zhao, G. Haghiashtiani, SZ Guo, MY He, R Su, ZJie Zhu, DB Bhuiyan, P. Murugan, FB Meng, SH Park, CC Chu, BM Ogle, BR Konety, RM Sweet*, and MC McAlpine*, “3D Printed Organ Models with Physical Properties of Tissue and Integrated Sensors”, Advanced Materials Technology,(DOI: 10.1002/admt.20170023)
  3. JingLiu, Pei Wang, Chih-Chang Chu, Tingfei Xi, “Arginine-leucine based poly (ester urea urethane) coating for Mg-Zn-Y-Nd alloy in cardiovascular stent applications”, Arginine-leucine based poly (ester urea urethane) coating for Mg-Zn-Y-Nd alloy in cardiovascular stent applications”, Colloids and Surfaces B: Biointerface, 159: 78-88, (2017) (IF 4.152)
  4. Jing Liu, Pei Wang, Chih-Chang Chu, and Tingfei Xi, “A novel biodegradable and biologically functional arginine-based poly(ester urea urethane) coating for Mg–Zn–Y–Nd alloy: enhancement in corrosion resistance and biocompatibility”, J. Mater Chem, Part B, 5:1787-1802, (2017) (IF 4.543)
  5. Ke-Mai Pei, Chih-Chang Chu, “Molecular dynamic simulations of a new family of synthetic biodegradable amino acid-based poly(ester amide) biomaterials: Glass transition temperature and adhesion behavior”, Materials Today Chemistry. 4:90-96, (2017).
  6. C. C. Chu, “Suture Materials” IN: Kirk-Othmer Encyclopedia of Chemical Technology, Wiley and Son, New York, March 2017, DOI: 10.1002/0471238961.1921202112052309.a01.pub3
  7. Ying Ji, Shuo Shanb Mingyu He, Chih-Chang Chu, “A novel pseudo-protein based biodegradable nano-micellar platform for the delivery of anti-cancer drug: Photo-enhanced micellar structural stability, Unique intracellular trafficking and In vitro therapeutic effect in human colon cancer cells”, Small, 13(1): 1-17, (2017) (IF 8.32)
  8. Ying Ji, Jihui Zhao, Chih-Chang Chu, “Biodegradable Nanocomplex from Hyaluronic acid and Arginine based Poly(ester amide)s as the Delivery Vehicles for Improved Photodynamic Therapy of Multidrug Resistant Tumor Cells: An In Vitro Study of the Performance of Chlorin e6 Photosensitizer”, J. Biomed. Mater. Res Part A, 105A:1487–1499, (2017) (IF 3.25).
  9. Mingyu He, Lillian Ro, Jing Liu, Chih-Chang Chu, “Folate Decorated Arginine Based Poly(ester urea urethane) Nanoparticles As Carriers for Gambogic Acid And Effect On Cancer Cells”, J. Biomed. Mater. Res. Part A 105A: 475–490, (2017) (IF3.25)
  10. Mingyu He, Alicia Potuck, Julie C. Kohn, Katharina Fung, Cynthia A. Reinhart-King, Chih-Chang Chu, “Self-assembled cationic biodegradable nanoparticles from pH-responsive Amino Acid-based Poly(ester urea urethane)s and their application as a drug delivery vehicle”, Biomacromolecules, 17(2): 523-537, (2016) (Impact factor 5.583).
  11. C. C. Chu, “Novel Synthetic Biodegradable Arginine-Rich Implantable Biomaterials And Devices For Human Body Repair And Reconstruction”, IN: L-Arginine: Structure, Dietary Sources and beneficial Effects, Editor Benjamin L. Soto, Nova Science Publisher, New York, Chapter 4, pp 89-126, (2016).
  12. Daniel Knecht and C. C. Chu, “A Novel Therapeutic for Diabetic Retinopathy: Mast Cell Stabilizer Impregnated Synthetic Biodegradable Amino Acid-Based Poly(ester amide) Rods”,  IN:  Biodegradable Polymers, Volume 1: Advancement in Biodegradation Study and Applications”, C. C. Chu (Editor), Nova Science Publisher, New York, Chapter 9, Dec. 2015.
  13. Janet L. Huie, J. Anastasia Nichols, Julien P. Fey, David Burns, Alicia Potuck and Chih-Chang Chu, “Novel Supercritical Carbon Dioxide Sterilization of Absorbable Sutures and New Amino Acid-based Biomaterials as Suture Coating”, IN: Biodegradable Polymers, Volume 1: Advancement in Biodegradation Study and Applications”, C. C. Chu (Editor),  Nova Science Publisher, New York, Chapter 14, Dec. 2015.
  14. C. C. Chu, “An Overview of A Novel Family of Nature-Inspired Design of Biodegradable Functional Amino Acid-based Poly(ester amide) Biomaterials: New Development, Property and Biomedical Applications”, IN: Biodegradable Polymers, Volume 2: New Biomaterial Advances and Challenges, C. C. Chu (Editor), Nova Science Publisher, New York, Chapter 3, Dec. 2015.
  15. MingYu He and C. C. Chu, “The New Functional Segmented Urethanes Biomaterials for Biomedical Studies: Design for Biocompatibility, Biodegradability, Self-assembly in Nanoscale”, IN: Biodegradable Polymers, Volume 2: New Biomaterial Advances and Challenges, C. C. Chu (Editor), Nova Science Publisher, New York, Chapter 4, Dec. 2015.
  16. Yan Zhang, Jinhong Li, Meidong Lang, and Chih-Chang Chu, “Biodegradable Functionalized Aliphatic Polyester: Preparation and Biomedical Application”, IN: Biodegradable Polymers, Volume 2: New Biomaterial Advances and Challenges, C. C. Chu (Editor), Nova Science Publisher, New York, Chapter 9, Dec. 2015.

 17.            De-Qun Wu, Jun Wu, Xiao-Hong Qin and Chih-Chang Chu, “From macro to micro to nano: development of a novel lysine based hydrogel platform and the enzyme triggered self-assembly of macro hydrogel into nanogel”, J. Material Chem. Part B, 3: 2286-2294, (2015).

18.            Alicia N. Potuck, Beth L. Weed, Cynthia A.  Leifer, C.C. Chu, “Electrostatically Self-assembled Biodegradable Microparticles from Pseudo-Proteins and Polysaccharide: Fabrication, Characterization and Biological Properties”, Biomacromolecules, 16(2): 564-577, (2015).

19.            J. Liu, X.L. Liu, T.F. Xi, C.C. Chu, " A Novel Pseudo-Protein-based Biodegradable Coating for Magnesium Substrate: In vitro corrosion phenomena and cytocompatibility," J. Mater. Chem, Part B 3: 878-893, (2015).

20.        Karina A. Hernandez, Rachel Campbell Hooper, Tatiana Boyko, Alyssa J. Reiffel Golas,

Michel van Harten, D.Q. Wu, Andrew Weinstein, C.C. Chu, Jason A. Spector, “Reduction of Suture Associated Inflammation after 28 days using Novel Biocompatible Pseudo-Protein Poly (ester amide) Biomaterials”, J. Biomed. Mater. Res. Part B Applied Biomaterials,103B:457 - 463, (2015)

21.        Gunjan Gakhar, Huixian Liu, Roquian Shen, Douglas Scherr, D. Q. Wu, David Nanus and C.C. Chu, “Anti-tumor Effect of Novel Cationic Biomaterials in Prostate Cancer”, Anticancer Research, 34: 3981 – 3990 (2014).

22.        Xuan Pang, Jun Wu, Chih-Chang Chu and Xuesi Chen, “Synthesis and Characterization of Novel Cationic Hybrid Hydrogels from Pendant Functional Amino Acid-based Poly(ester amide)s”, Acta Biomaterials, 10 (7): 3098-3107, (2014).

23.        Jun Wu, Xin Zhao, Dequn Wu, Chih-Chang Chu, “Development of a biocompatible and biodegradable hybrid hydrogel platform for sustained release of ionic drugs”, J. Mater. Chem. Part B 2(38): 6660-6668, (2014).

24.        Mingyu He, Alicia Potuck; Yi Zhang, C. C. Chu, “Arginine based polyester amide / polysaccharide hydrogels and their biological response”, Acta Biomaterial, 10 (6): 2482-2494, (2014).

25.        Mingyu He and C. C. Chu, “Dual Stimuli Responsive Glycidyl Methacrylate Chitosan-Quaternary Ammonium Hybrid Hydrogel and Its Bovine Serum Albumin Release”, J. Appl. Polym. Sci, 130 (5): 3736-37845, (2013).

26.        D. Q. Wu, J. Wu, and C. C. Chu, “A novel family of biodegradable hybrid hydrogels from arginine-based poly(ester amide) and hyaluronic acid precursors”, Soft Matter, 9: 3965-3975, (2013)

27.        Mingyu He and C. C. Chu, “A new family of functional biodegradable Arginine-based polymer urea urethanes: synthesis, characterization and biodegradation”, Polymer, 54: 4112-4125 (2013)

28.        X. H. Qin, D. Q. Wu, and C. C. Chu, “Dual functions of polyvinyl alcohol (PVA): fabricating particles and electrospinning nanofibers applied in controlled drug release”, J. Nanoparticle Res., 15: 1395 - 1409   (2013)

29.        Jun Wu and C. C. Chu, “Water insoluble cationic poly (ester amide)s: synthesis, characterization and applications”, J. Mater. Chem.  B, 1:353 – 360, (2013)

30.        C. S. Chen, X. D. Xu, Y. Wang, J. Yang, H. Z. Jia, H. Cheng, C. C. Chu, R. X. Zhuo, X. Z. Zhang, “A peptide nanofibrous indicator for eye-detectable cancer cell identification”, Small, 9 (6): 920-926, (2013)

31.        C. C. Chu, “Types and Properties of Surgical Sutures", IN: Biotextiles as Medical Implants, B.S. Gupta, M. King and R. Guidoin (eds), Woodhead Publishing Series in Textiles No. 113, Cambridge, England,  Part 2 Application, Chapter 10, Oct. 2013, pp 232-274.

32.        C. C. Chu, ““Materials for Absorbable and Non-absorbable Surgical Sutures”, IN: Biotextiles as Medical Implants, B.S. Gupta, M. King and R. Guidoin (eds), Woodhead Publishing Series in Textiles No. 113, Cambridge, England,  Part 2 Application, Chapter 11, Oct. 2013.

33.        Jun Wu Dequn Wu Martha A. Mutschler, Chih-Chang Chu, “Cationic Hybrid Hydrogels from Amino-Acid-Based Poly(ester amide): Fabrication, Characterization, and Biological Properties”, Advanced Functional Materials, 22 (18): 3815-3823 (2012).

34.        Jun Wu and Chih-Chang Chu, “Block Copolymer of Poly (ester amide) and Polyesters: Synthesis, Characterization, and in vitro Cellular Response”, Acta Biomaterials, 8 (12): 4314-4323, (2012).

35.        Jun Wu, Dai Yamanouchi, Bo Liu and C. C. Chu, “Biodegradable Arginine-based Poly(ether ester amide)s as Non-viral DNA delivery Vector and their Structure – Function Study”,  J. Mater. Chem. 22: 18983 – 18991, (2012).

36.        LA Hockaday, KH Kang, NW Colangelo, PYC Cheung, B Duan, E Malone, J Wu, LN Girardi, LJ Bonassar, H Lipson, CC Chu and JT Butcher, “Rapdi 3D printing of anatomically accurate and mechanically heterogeneous aortic valve hydrogel scaffolds”, Biofabrication, 4 (3): 1-12, Sept (2012).

37.        Yuan-Jia Pan, Yuan-Yuan Chen, Dong-Rui Wang, Chuan Wei, Jia Guo, Da-Ru Lu, Chih-Chang Chu, Chang-Chun Wang, “Redox/pH dual stimuli-responsive biodegradable nanohydrogels with varying responses to dithiothreitol and glutathione for controlled drug release”, Biomaterials 33(27): 6570-6579, (2012).

38.        K. Guo and C. C. Chu, “Synthesis and Characterization of Poly-ε-caprolactone-containing Amino Acid-based Poly(ether ester amide)s”, J. Appl. Polym. Sci. 125(1): 812-819, (2012).

39.        H. Song and C. C. Chu, “Synthesis and Characterization of A New Family of Cationic Poly(ester amide)s and Their Biological Properties”, J. Appl. Polym. Sci. 124 (5): 3840–3853, (2012).

40.        Chao Zhong and C. C. Chu, Biomimetic Mineralization of Acid Polysaccharide-based Hydrogels: Towards Porous 3-Dimensional Bone-like Biocomposites”, J. Mater. Chem, 22(13): 6080-6087, (2012)

41.        H. Xu, J. Wu, C. C. Chu, M. L. Shuler, “Development of disposable PDMS micro cell culture analog devices with photopolymerizable hydrogel encapsulating living cells”, Biomed Microdevices, 14:409-418, (2012).

42.        C. C. Chu, “Novel Biodegradable Functional Amino Acid-based Poly(ester amide) Biomaterials: Design, Synthesis, Property and Biomedical Applications”, J. Fiber Bioengineering and Informatics” 5(1): 1-31, (2012)

43.        C. C. Chu,  “Biodegradable Polymeric Biomaterials: An Updated Overview”, IN: Biomaterials – Principles and Practices, Ed: Joyce Y. Wong, Joseph D. Bronzino, and Donald R. Peterson, CRC Press,  Boca Raton, Fla, Dec. 6, 2012, Chapter 5.

44.        J. T. Butcher, L. Hockaday, K. Kang, N. Colangelo, J. Wu and C. C. Chu, "High fidelity 3D tissue printing of scalable anatomically accurate living aortic valves," Tissue Engineering Part A 17(3-4), 545 (2011)

45.        Guoming Sun, C. C. Chu, “Biodegradable Nanospheres Self-Assembled from Complementary Hydrophilic Dextran Macromers”, Carbohydrate Polymers, 86(2): 910-916, (2011).

46.        E. Chkhaidze, D. Tugushi, D. Kharadze1, Z. Gomurashvili, C. C. Chu, R. Katsarava, “New unsaturated biodegradable poly(ester amide)s composed of fumaric acid, leucine and α,ω-alkylene diols”, J Macromol Sci Part A - Pure & Appl Chem. 48(7): 544 -555, (2011).

47.        Mingxiao Deng, Jun Wu, Cynthia A. Reinhart-King, and C. C. Chu, “Biodegradable Functional Poly(ester amide)s with Pendant Hydroxyl Functional Groups: Synthesis, Characterization, Fabrication and In Vitro Cellular Response”, Acta Biomaterials 7:1504-1515, (2011).

48.        Jun Wu, Martha A. Mutschler, C. C. Chu, “Synthesis and Characterization of Ionic Charged Water Soluble Arginine-based Poly (ester amide)”, J. Mater. Sci. Mater in Med. 22:469–479, (2011)

49.        Joshua A. Horwitz, Katrina M. Shum, Josephine C. Bodle, MingXiao Deng, C. C. Chu, Cynthia A. Reinhart-King, “Biological performance of biodegradable amino acid-based poly(ester amide)s: Endothelial cell adhesion and inflammation in vitro”, J. Biomed. Mater. Res. Part A, 95: 371-380 (2010).

50.        Huijun Wu, Jintu Fan, C. C. Chu and Jun Wu, “Electrospinning of small diameter 3-D nanofibrous tubular scaffolds with controllable nanofiber orientations for vascular grafts”, J Mater. Sci., Mater. In Med, 21:3207-3215, (2010)

51.        Chao Zhong and C. C. Chu, On the Origin of Amorphous Cores in Biomimetic CaCO3Spherulites: New Insights into Spherulitic Crystallization”, J. Crystal Growth and Design 10 (12): 5043–5049, (2010).

52.        Xuan Pang, Jun Wu, Cynthia Reinhart-King, and C. C. Chu, “Synthesis and characterization of functionalized water soluble cationic poly(ester amide)s”, J. Polym. Sci. Part A: Polymer Chemistry, 48: 3758–3766. (2010).

53.        Chao Zhong,, Jun Wu, C.A. Reinhart-King, C. C. Chu, “Synthesis, characterization and cytotoxicity of photo-crosslinked maleic chitosan-PEGDA hybrid hydrogels”, Acta Biomaterials, 6(10):3908-3918, (2010).

54.        Xuan Pang and C. C. Chu, “Synthesis, Characterization and Biodegradation of Poly(ester amide)s based Hydrogels”, Polymer, 51: 4200-4210, (2010).

55.        K. Guo and C. C. Chu, "Synthesis of Biodegradable Amino Acid-based Poly(ester amide) and Poly(ether ester amide) with Pendant Functional Groups", J. Appl. Polym. Sci. 117(6): 3386-3394, (2010).

56.        Guoming Sun and C. C. Chu, "Impregnation of Tubular Self-Assemblies into Dextran Hydrogels", Langmuir, 26(4): 2831-2838, (2010).

57.        Xuan Pang and C. C. Chu, "Synthesis, Characterization and Biodegradation of Functionalized Amino Acid-based Poly(ester amide)s", Biomaterials, 31(14): 3745-3754, (2010).

58.        Guoming Sun and C. C. Chu, "Impregnation of Tubular Self-Assemblies into Dextran Hydrogels", Langmuir, 26(4): 2831-2838, (2010).

Research and teaching in the field of biomaterials and medical devices for human body repair

Use a multidisciplinary approach and real examples to illustrate how biomaterials could be used in human body reconstruction.  The latest research informations from my lab and others are introduced to students.  Guest speakers from industry and medical communities may be invited to give students different perceptive of the multidisciplinary integration of the field.

  • BME 5390 - Biomedical materials and devices for human body repair
  • FSAD 4390 - Biomedical Materials and Devices for Human Body Repair
  • Postdoc 1978 - University of Alabama Chemistry
  • Ph.D. 1976 - Florida State University Chemistry
  • B.S. 1969 - Tamkang University, Taiwan, China Chemistry