Qi Research Lab
Welcome to the Qi laboratory website. Currently, the laboratory has two focuses, Unfolded Protein Response (UPR) and Inflammation in Obesity. We are composed of graduate students, postdoctoral fellows, technician and undergraduate students.
Unfolded protein response (UPR): We are interested in transcriptional regulation of UPR in the context of the "conformational diseases" such as diabetes and obesity. The questions we address in particular are: what is the physiological role of UPR in diabetes and obesity? how do other signaling pathways regulate UPR? We use biochemical, genetic, immunological and high throughput approaches in both mouse- and cell culture-models to address these fundamental questions.
See our recent patent application "Targeting Physiological Unfolded Protein Response" to quantitate ER stress.
Inflamed obesity: Obesity is often associated with infiltration of macrophages into adipose tissues, which is thought to contribute significantly to insulin resistance. We are interested in the molecular basis of communication between macrophages and adipocytes in adipose tissues. To this end, we use gene knockout and knockdown approaches to investigate the genetic control of inflammation in the context of obesity.
Our laboratory is located at the center of the Cornell Ithaca campus. We have extensive interaction with members in Department of Molecular Biology and Genetics, Division of Nutritional Sciences and the Vet School. Dr. Qi is a member of Genes & Development (G&D), Biochemistry, Molecular & Cellular Biology (BMCB), Nutritional Sciences (NS), Molecular and Integrative Physiology (MIP) and Immunology & Infectious Diseases (Immunol) graduate fields.
Our laboratory aims to bring a standard excellence to what we do as individuals and as a laboratory. We strive to create an environment that is fair, respectful, collegial and conducive to new ideas. We welcome highly self-motivated individuals (postdoctoral fellows and graduate students) to join us. Please feel free to visit us (Rm. 307/309 of the Biotechnology Building) or contact Dr. Ling Qi.
Career: Dr. Qi received his undergraduate degree in Microbiology from the Fudan University, China in 1997 and his Ph.D. in Immunology with Dr. Suzanne Ostrand-Rosenberg from the University of Maryland in 2001. He was a postdoc at Johns Hopkins University Medical School with Dr. Carol Greider, 2009 Nobel Laureate (2001-2004) and the Salk Institute with Dr. Marc Montminy (2004-2007) prior to joining the faculty of Cornell University in 2007 as an Assistant Professor.
Awards: Dr. Qi became a Leukemia and Lymphoma Society Postdoctoral Fellow in 2002 and Juvenile Diabetes Research Foundation Postdoctoral Fellow in 2005. In 2008, he was the recipient of the Junior Faculty Award from the American Diabetes Association and the Young Investigator Award from the American Federation for Aging Research. In 2011, he was awarded the Young Investigator Award by the American Society for Nutrition. In 2012, he was awarded the Career Development Award by the American Diabetes Association.
WE ARE GRATEFUL FOR SUPPORT FROM THE FOLLOWING ORGANIZATIONS