Patrick J. Stover |
| Professor & Division Director |
| 127 Savage Hall |
| DNS |
| |
| Phone: (607) 255-8001 |
| Fax: (607) 254-5177 |
| Email: pjs13@cornell.edu |
| View Cornell Contact Info |
Biographical Statement:
Patrick Stover received his Bachelors of Science degree in Chemistry from Saint Joseph's University in 1987, and his PhD degree in Biochemistry and Molecular Biophysics in 1990 from the Medical College of Virginia. He conducted his postdoctoral research at the University of California at Berkeley in Nutritional Sciences from 1991 to 1994. He became an Assistant Professor of Nutritional Biochemistry in 1994 at Cornell University and currently serves as Professor and Director of the Division of Nutritional Sciences at Cornell University and as Director of the United Nations Food and Nutrition Programme for Human and Social Development.
The Stover research group investigates the biochemical, genetic and epigenetic mechanisms that underlie the relationships between the B-vitamin folate and human pathologies including neural tube defects, cardiovascular disease and cancer. Specific interests include the regulation of folate-mediated one-carbon metabolism and genome expression and stability, the molecular basis of the fetal origins hypothesis, development of mouse models to elucidate mechanisms of folate-related pathologies, and translational control of gene expression. In 1996 he received the Presidential Early Career Award for Scientists and Engineers from President William Jefferson Clinton. He received the ERL Stokstad Award in Nutritional Biochemistry from the American Society for Nutritional Sciences in 1999 and has been selected as an Outstanding Educator four times by Cornell Merrill Presidential Scholars. He is a Member of the Food and Nutrition Board of the Institute of Medicine, National Academy of Sciences. He serves on the editorial boards for the Annual Review of Nutrition, The American Journal of Clinical Nutrition and The Journal of Biological Chemistry.
|
Current Professional Activities:
Director, Division of Nutritional Sciences
Director, United Nations University Food and Nutrition Programme for Social Development
Cornell University Graduate Field Membership: Nutrition, Biochemistry, Molecular and Cellular Biology
Member of the Food and Nutrition Board of the Institute of Medicine, National Academy of Sciences
Editorial Boards: Annual Review of Nutrition, The American Journal of Clinical Nutrition, The Journal of Biological Chemistry
PhenX Consensus Measures for Phenotypes and Exposures. Chair, Nutrition and Dietary Supplements Committee. National Human Genome Research Institute (NIH) and RTI International
Chair, Public Policy and Communications Committee, American Society for Nutrition
Spokesperson, American Society for Nutrition |
Courses Taught:
Bio G 200 - Research Apprenticeship
BioBM 400 - Undergraduate Research
BioBM 733 - Advanced Biochemistry Lecture Series
NS 320 - Human Biochemistry
NS 400 - Directed Readings
NS 401 - Student Research
NS 475 - Mechanisms Underlying Mammalian Developmental Defects
NS 600 - Independent Study - Nutritional Genomics
NS 704 - Grant Writing
|
Education:
PhD 1990 - Medical College of Virginia, Biochemistry and Molecular Biophysics
BS 1986 - Saint Joseph's University, Chemistry |
Current Research Activities:
Regulation of folate-mediated one-carbon metabolism; Metabolic regulation of genome methylation and stability; Folate-genome interactions in colon cancer and developmental anomalies; Nuclear folate metabolism; Mechanisms of folate catabolism.
|
Selected Publications:
MacFarlane AJ, Perry CA, Girnary HH, Gao D, Allen RH, Stabler SP, Shane B, and Stover PJ. 2009. Mthfd1 is an Essential Gene in Mice and Alters Biomarkers of Impaired One-Carbon Metabolism. J. Biol. Chem. 284(3):1533-9.
Fox, J. T. and Stover, P. J. 2008 Folate-Mediated One-Carbon Metabolism Vitam. Horm. 79:1-44.
Stover, P. J. and MacFarlane, A. 2008. Mouse models to elucidate mechanisms of folate-related cancer pathologies. Nutr Rev. 66 Suppl 1:S54-8.
Stover, P. J. and Caudill, M. A. 2008. Genetic and Epigenetic Contributions to Human Nutrition and Health: managing genome-Diet Interactions. J Am Diet Assoc. 108(9):1480-7.
MacFarlane, A. and Stover, P. J. The Gastrointestinal Tract in Health and Disease. Encyclopedia of Public Health. International Encyclopedia of Public Health First Edition (2008) vol. 3 pp. 9-19.
MacFarlane, A. and Stover, P. J. 2008. Convergence of Genetic, Nutritional and Inflammatory Factors in Gastrointestinal Cancers. Nutr Rev. 2007 65(12 Pt 2):S157-66
Field, MS, Anguera, MC, Page, R and Stover PJ 2008. 5,10-Methenyltetrahydrofolate Synthetase Activity is Increased in Tumors and Modifies the Efficacy of Antipurine LY309887. Arch. Biochem. Biophys. 481(2):145-50.
Macfarlane AJ, Liu X, Perry CA, Flodby P, Allen RH, Stabler SP, and Stover PJ. 2008. Cytoplasmic serine hydroxymethyltransferase regulates the metabolic partitioning of methylene-tetrahydrofolate but is not essential in mice. J. Biol. Chem. 283(38):25846-53.
Woeller, C. F., Fox, J. T., Perry, C. and Stover, P. J. 2007. A Ferritin-responsive Internal Ribosome Entry Site Regulates Folate Metabolism. J. Biol. Chem. 282(41):29927-35.
Anderson, D.D., Woeller, C.F., and Stover, P. J. 2007. SUMO-1 Modification of Thymidylate Synthase and Dihydrofolate Reductase. Clin. Chem. Lab. Med. 45(12): 1760-1763.
Woeller, C. F., Anderson, D. D., Szebenyi, D. M. E. and Stover, P. J. 2007. Evidence for SUMO-Dependent Nuclear Location of the Thymidylate Biosynthesis Pathway. J. Biol. Chem. 282(24):17623-31.
Perry, C. Yu, A. S., Chen, J., Matharu K. and Stover, P. J. 2007. Effect of Vitamin B6 Availability on Serine Hydroxymethyltransferase in MCF-7 Cells. Arch. Biochem. Biophys. 462(1):21-27.
Field, M. S., Szebenyi, D. M. E. and Stover, P. J. 2007. Inhibition of 5,10-Methenyltetrahydrofolate Synthetase. Arch. Biochem. Biophys. 458(2):194-201.
Stover, P. J. 2007. Human Nutrition and Genetic Variation. Food and Nutrition Bulletin 28:1 S101-S115.
Beaudin, A. and Stover, P. J. 2007. Folate-mediated One-carbon Metabolism and Neural Tube Defects - Balancing Genome Synthesis and Gene Expression. Birth Defects Research Part C: Embryo Today. 81(3):183-203
Anguera, M. C. and Stover, P. J. 2006. Methenyltetrahydrofolate Synthetase is a High-Affinity Catecholamine-Binding Protein. Arch. Biochem. Biophys. 455(2):175-87.
Anguera MC, Field MS, Perry C, Ghandour H, Chiang EP, Selhub J, Shane B, Stover PJ. 2006. Regulation of folate-mediated one-carbon metabolism by 10-formyltetrahydrofolate dehydrogenase. J. Biol Chem. 281(27):18335-42.
Stover PJ 2006. Influence of human genetic variation on nutritional requirements. Am J Clin Nutr Feb;83(2):436S-442S.
Field MS, Szebenyi DM, Stover PJ 2006. Regulation of de novo purine biosynthesis by methenyltetrahydrofolate synthetase in neuroblastoma. J Biol Chem Feb 17;281(7):4215-4221.
Perry C, Sastry R, Nasrallah IM, Stover PJ (2005) Mimosine attenuates serine hydroxymethyltransferase transcription by chelating zinc. Implications for inhibition of DNA replication. J Biol Chem Jan 7;280(1):396-400.
Lim U, Peng K, Shane B, Stover PJ, Litonjua AA, Weiss ST, Gaziano JM, Strawderman RL, Raiszadeh F, Selhub J, Tucker KL, Cassano PA (2005) Polymorphisms in cytoplasmic serine hydroxymethyltransferase and methylenetetrahydrofolate reductase affect the risk of cardiovascular disease in men. J Nutr Aug;135(8):1989-1994.
Stover PJ (2005) Ferritin and serine hydroxymethyltransferase. In: Nutrient and Gene Interactions in Cancer (Shils ME, ed.) Chapter 11. CRC Press (in press)
Anguera MC, Liu X, Stover PJ (2004) Cloning, expression, and purification of 5,10-methenyltetrahydrofolate synthetase from Mus musculus. Prot Expr Purif Jun;35(2):276-283.
Stover PJ (2004) Nutritional genomics. Physiol Genomics Jan 15;16(2):161-165. Review.
Stover PJ (2004) Physiology of folate and vitamin B12 in health and disease. Nutr Rev Jun;62(6 Pt 2):S3-12; discussion S13. Review.
Anguera MC, Suh JR, Ghandour H, Nasrallah IM, Selhub J, Stover PJ (2003) Methenyltetrahydrofolate synthetase regulates folate turnover and accumulation. J Biol Chem Aug 8;278(32):29856-29862.
Zanetti KA, Stover PJ (2003) Pyridoxal phosphate inhibits dynamic subunit interchange among serine hydroxymethyltransferase tetramers. J Biol Chem Mar 21;278(12):10142-10149.
Garza C, Stover P (2003) The role of science in identifying common ground in the GMO debate. Trend Food Tech 14:182-190.
Stover PJ (2003) New paradigms for nutrient control of genome translation. Nutr Rev Dec;61(12):427-431. Review.
Herbig K, Chiang EP, Lee LR, Hills J, Shane B, Stover PJ (2002) Cytoplasmic serine hydroxymethyltransferase mediates competition between folate-dependent deoxyribonucleotide and S-adenosylmethionine biosyntheses. J Biol Chem Oct 11;277(41):38381-38389. Epub 2002 |
Administrative Responsibilities:
Director, Division of Nutritional Sciences
Director, United Nations University Food and Nutrition Programme for Social Development
|
Current Extension Activities:
The Director of the Division of Nutritional Sciences provides oversight of DNS extension activities. |
|
The information on this bio page is taken from the CHE Annual Report. |
|
