Paul D. Soloway |
| Professor |
| 211 Weill Hall |
| DNS |
| |
| Phone: (607) 254-6444 |
| Fax: (607) 254-6444 |
| Email: pds28@cornell.edu |
| View Cornell Contact Info |
Biographical Statement:
Formal education includes a BA 1979 from Cornell University in Biology and a PhD 1989 from Princeton University in Molecular Biology. Post doctoral training was at MIT and the Whitehead Institute from 1998-1994. Independent positions as a Principal Investigator were at Roswell Park Cancer Institute from 1994-2002 and at Cornell University from 2002 to the present. Area of expertise is mouse molecular genetics with a focus on mechanisms controlling placement of epigenetic modifications including DNA and histone methylation in the mouse genome and technology development for genome wide epigenetic profiling. |
Current Professional Activities:
Research: 50%
Teaching: 50%
|
Courses Taught:
NS / BioGD 490 - Manipulating the Mouse Genome
NS / BioGD 608 - Epigenetics
1 lecture each in:
- 7th Annual Jackson Laboratory Workshop on the Pathology of Mouse Models for Human Disease, Cornell University
- NS 6320
- Cornell Cooperative Extension Fall Nutrition Update
|
Education:
Post-doc 1994 - Whitehead Institute / MIT, Molecular Genetics - Advisor, R. Jaenisch
Ph.D. 1989 - Princeton University, Molecular Genetics - Advisor, T. Shenk
BA 1979 - Cornell University, Biochemistry |
Current Research Activities:
Current research activites are in the area of epigenetics and includes three separate sets of projects. One of these seeks to characterize the mechanisms regulating the epigenetic phenomena of DNA and histone methylation in mice using the Rasgrf1 gene as a model. These methylation events are potent regulators of gene expression and respond to environmental variables, including nutritional variables, in ways that are stable and inheritable. The second set of projects seeks to identify novel imprinted genes using both experimental and bioinfomatic approaches. These efforts have identifed several previously unrecognized imprinted loci. The third project is being conducted in collaboration with Harold Craighead. The goal is to develop single molecule profiling of multiple epigenetic states, simultaneously and genome wide using a nanofluidic device. |
Administrative Responsibilities:
Chair, College of Agriculture and Life Sciences Faculty Senate
|
Selected Publications:
Wang, X., Sun, Q., McGrath, S. D., Mardis, E. R., Soloway, P. D., and Clark, A. G. (2008) "Transcriptome-wide identification of novel imprinted genes in neonatal mouse brain" PLoS ONE 3:(12), e3839
Lindroth, A. M., Park, Y. J., McLean, C. M., Dokshin, G. A., Persson, J. M., Herman, H., Pasini, D., Miro, X., Donohoe, M. E., Lee, J. T., Helin, K., and Soloway, P. D. (2008) "Antagonism between DNA and H3K27 Methylation at the Imprinted Rasgrf1 Locus" PLoS Genetics 4:(8), e1000145
Soloway, P. D. (2006). "Paramutable Possibilities." Nature 441: 413-414.
Holmes, R. and P. D. Soloway (2006). "Regulation of imprinted DNA methylation." Cytogenet Genome Res 113(1-4): 122-9.
Holmes, R., Y. Chang and P. D. Soloway (2006). "Timing and Sequence Requirements Defined for Embryonic Maintenance of Imprinted DNA Methylation at Rasgrf1." Mol Cell Biol 26(24): 9564-70.
Yoon, B.-J., H. Herman, B. Hu, Y. J. Park, A. M. Lindroth, A. Bell, A. G. West, Y. Chang, A. Stablewski, J. C. Piel, D. I. Loukinov, V. Lobanenkov and P. D. Soloway (2005). "Rasgrf1 Imprinting is Regulated by a CTCF-dependent Methylation-Sensitive Enhancer Blocker." Mol Cell Biol 25(24): 11184?11190.
Herman, H., M. Lu, M. Anggraini, A. Sikora, Y. Chang, B. J. Yoon and P. D. Soloway (2003). "Trans allele methylation and paramutation-like effects in mice." Nat Genet 34(2): 199-202.
Fitzpatrick, G. V., P. D. Soloway and M. J. Higgins (2002). "Regional loss of imprinting and growth deficiency in mice with a targeted deletion of KvDMR1." Nat Genet 32: 426 - 431.
de la Puente, A., J. Hall, Y. Z. Wu, G. Leone, J. Peters, B. J. Yoon, P. Soloway and C. Plass (2002). "Structural characterization of Rasgrf1 and a novel linked imprinted locus." Gene 291(1-2): 287-97.
Yoon, B. J., H. Herman, A. Sikora, L. T. Smith, C. Plass and P. D. Soloway (2002). "Regulation of DNA methylation of Rasgrf1." Nat Genet 30(1): 92-6.
Plass, C. and P. D. Soloway (2002). "DNA methylation, imprinting and cancer." Eur J Hum Genet 10(1): 6-16.
|
|
The information on this bio page is taken from the CHE Annual Report. |
|
