Andre Bensadoun

Andre Bensadoun

Dr Bensadoun's professional expertise is in lipid transport and more specifically in the biochemistry, structure and function of lipolytic enzymes(lipoprotein lipase and hepatic lipase) and lipase-binding proteins such as heparan sulfate proteoglycans(syndecans and glypicans) and GPIHBP1 (glycosylphosphatidylinositol anchored HDL binding protein). 

Dr Bensadoun is engaged mainly in research.  He has currently an appointment as a Graduate School Professor.  He has membership ifollowing graduate Fields: Nutrition; Biochemistry, Molecular and Cell Biology; Molecular and integrative Physiology.

Work in my laboratory is mainly concerned with molecular aspects of lipid transport, the study of how lipids are transported between various organs in the body. More specifically our work is concerned with the characterization and regulation of lipases and their receptors, proteins that play major roles in removing lipids from blood. Lipases degrade triglycerides and phospholipids in blood and control the removal of cholesterol from plasma. Our effort has concentrated on two enzymes, lipoprotein lipase(LPL) and hepatic lipase(HL) and the major receptors for these enzymes, syndecans and glypicans, two classes of proteoglycans and a newly discovered receptor, GPIHBP1 (glycosylphosphatidyl inositol anchored HDL binding protein). Lipases because of their impact on plasma triglycerides and cholesterol concentrations play a major role in arterial wall plaque formation and the atherosclerotic process.  We are currently focusing our efforts on studies of the structure, molecular mechanism and function of glycosylphosphatidylinositol-HDL-binding protein 1(GPIHBP1). GPIHBP1 is a newly discovered protein which is essential to normal metabolism of triglyceride-rich lipoproteins. Mice deficient in GPIHBP1 develop gross hypertriglyceridemia with plasma concentration in excess of 3000 mg triglyceride /100ml. Recent results suggest that lipoprotein lipase (LPL), the enzyme responsible for triglyceride hydrolysis is mis-localized in GPIHBP1 deficient mice. Light microscopy experiments show that the enzyme is located in the basement membrane instead of its typical location on the luminal surface of the endothelium. In vitro transport experiments with cultured endothelial cells in trans-well dishes demonstrate that cells expressing GPIHBP1 transport LPL from the basal lateral surface to the apical surface. We are currently exploring the molecular mechanisms underlying this property of GPIHBP1 in trans-endothelial transport. Thiswork is being carried out in collaboration with Dr Stephen Young’s group in department of cardiology at UCLA.

Bordeaux University, France Baccalaureate, mathematics 1951
Toulouse University, France Eng. of ENSAT, engineering 1956
Toulouse University, France Lic. Sc. biology, 1956
Cornell University, Ithaca, NY Ph.D. nutrition 1960

I did not teach during 2012.

Supervises three technicians.

Hosseini, M., Ehrhardt, N., Weissglas-Volkov, D., Lai, C.M., Mao, H.Z., Liao, J.L., Nikkola, E., Bensadoun, A., Taskinen, M.R., Doolittle, M.H., Pajukanta, P., Peterfy, M. Transgenic expression and genetic variation of Lmf1 affect LPL activity in Mice and humans. Arterioscler.Thromb.Vasc.Biol. 32:1204-1210, 2012.  PMID: 22345169.

Bensadoun, A., Nesheim, M.C., Ross, A.C. Biography of Donald Berthold Zilversmit. J.Nutr.142:211-212, 2012.

Nyren, R., Chang, C.L., Lindstrom, P., Barmina, A., Vorrsjo, E., Ali, Y., Juntti-Berggren, L., Bensadoun, A., Young, S.G., Olivecrona, T., Olivecrona, G. Localization of lipoprotein lipase and GPIHBP1 in mouse pancreas:  Effects of diet and leptin deficiency.  BMC Physiol. Epub ahead of print; PMID: 23186339, 2012.

Adeyo, O., Goulbourne, C.N., Bensadoun, A., Beigneux, A.P., Fong, L.G., Young, S.G.  Glycosylphosphatidylinositol-anchored high-density lipoprotein-binding protein1 and the intravascular processing of triglyceride-rich lipoproteins.  J.Intern. Med. 272:528-540. 2012. PMID:23020258.

Gin, P., Goulbourne, C.N., Adeyo, O., Beigneux, A.P., Davies, B.S., Tat, S., Voss, C.V., Bensadoun, A., Fong, L.G., Young, S.G.  Hum. Mol. Genet. 21: 2961-2972. 2012. PMID: 22493000

Davies, B.S., Goulbourne, C.N., Barnes, R.H. 2^nd, Turlo, K.A., Gin, P., Vaughan, S., Vaux, D.J., Bensadoun, A., Beigneux, A.P., Fong, L.G., Young, S.G.  Assessing mechanisms of GPIHBP1 and lipoprotein lipase movement across endothelial cells.  J.Lipid Res. 53:2690-2697. 2012. PMID:23008484.