Ling Qi Research Site Unfolded protein response (UPR): We are interested in transcriptional regulation of UPR in the context of the "conformational diseases" such as diabetes and obesity. The questions we address in particular are: what is the physiological role of UPR in diabetes and obesity? how do other signaling pathways regulate UPR? We use biochemical, genetic, immunological and high throughput approaches in both mouse- and cell culture-models to address these fundamental questions. Inflamed obesity: Obesity is often associated with infiltration of macrophages into adipose tissues, which is thought to contribute significantly to insulin resistance. We are interested in the molecular basis of communication between macrophages and adipocytes in adipose tissues. To this end, we use gene knockout and knockdown approaches to investigate the genetic control of inflammation in the context of obesity. Our laboratory is located at the center of the Cornell Ithaca campus. We have extensive interaction with members in Department of Molecular Biology and Genetics, Division of Nutritional Sciences and Vet School. Ling is a member of Genes & Development (G&D), Biochemistry, Molecular and Cellular Biology (BMCB), Nutritional Sciences (NS) and Molecular and Integrative Physiology (MIP) graduate fields. Our laboratory aims to bring a standard excellence to what we do as individuals and as a laboratory. We strive to create an environment that is fair, respectful, collegial and conducive to new ideas. We welcome highly self-motivated individuals (postdoctoral fellows and graduate students) to join us. Please feel free to visit us (Rm. 307/309 of the Biotechnology Building) or contact Dr. Ling Qi. Career: Dr. Qi received his undergraduate degree in Microbiology from the Fudan University, China in 1997 and his Ph.D. in Immunology with Dr. Suzanne Ostrand-Rosenberg from the University of Maryland in 2001. He was a postdoc at Johns Hopkins University Medical School with Dr. Carol Greider, 2009 Nobel Laureate (2001-2004) and the Salk Institute with Dr. Marc Montminy (2004-2007) prior to joining the faculty of Cornell University in 2007 as an Assistant Professor. Dr. Qi became a Leukemia and Lymphoma Society Postdoctoral Fellow in 2002 and Juvenile Diabetes Research Foundation Postdoctoral Fellow in 2005. In 2008, he was the recipient of the Junior Faculty Award from the American Diabetes Association and the Young Investigator Award from the American Federation for Aging Research. Link to Ling's official Cornell web-bio page: http://www.human.cornell.edu/che/bio.cfm?netid=lq35 **************************** We are grateful to the support from
*************************** GRADUATE STUDENTS We will have one opening for a highly-motivated graduate student for 2010 (maybe 2 depending on the funding). Potential projects involve the role of physiological UPR and/or inflammation in metabolic syndrome. Interested students should contact Ling for potential rotation dates and projects. *************************** POSTDOCTORAL ASSOCIATE POSITION Inflammation and Metabolic Syndrome One position is available for a highly motivated individual to study the role of inflammation in obesity and diabetes (references check the publication page). Candidates should have a recent doctoral degree with a strong background in cellular immunology. Send CV and names of three references to: lq35@cornell.edu
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