Saurabh Mehta

 

Saurabh Mehta

Assistant Professor of Global Health, Epidemiology, and Nutrition
314 Savage Hall
 
Phone: (607) 255-2640 Fax: (607) 255-1033
Email: smehta@cornell.edu
View Cornell University Contact Info
 
Biographical Statement:

Dr. Mehta received his medical degree from the All India Institute of Medical Sciences (AIIMS) in New Delhi, India, and a Doctor of Science degree in Epidemiology and Nutrition from Harvard University, Cambridge, Massachusetts. He conducted his post-doctoral research in nutritional epidemiology at the Harvard School of Public Health. Dr. Mehta has over 10 years of experience in working in resource-limited settings in the areas of infectious diseases, particularly HIV and Tuberculosis, epidemiology, and nutrition. 

 
Current Research Activities:

The Mehta research group broadly works in the areas of infectious diseases, particularly HIV, Tuberculosis, and Neglected Tropical Diseases, and maternal and child health. The group focuses on the role of micronutrients in modulation of the immune response, perinatal health, and applying novel diagnostics and analytic methodologies to advance clinical care in resource-limited settings in India, Sub-Saharan Africa, and Latin America. Dr. Mehta’s research has identified a key role for vitamin D in reducing HIV disease progression and risk of HIV-related morbidities for the first time, and suggests vitamin D supplements could represent an inexpensive adjunct to anti-retroviral therapy. 

 

Vitamin D 

One of the group's projects is focused on vitamin D supplementation among patients with Tuberculosis, some of whom are co-infected with HIV. This randomized trial is expected to start recruiting participants in January 2014 in India (Clinicaltrials.gov #NCT01992263). The major outcomes of interest, in addition to treatment response, include immune competence and effect on vitamin D status. The group is also investigating the role of vitamin D in maternal and child health in a large cohort of pregnant women in partnership with colleagues at the St. John's Research Institute in Bangalore, India. In another study, Dr. Mehta is collaborating with the National Institute of Nutrition in Hyderabad, India to examine the association of vitamin D with immune activation in hospitalized children. In Kenya, the research group is focusing on shedding more light on the relationship of vitamin D status with vaccine responses among infants in collaboration with partners in New York. 

 

Biofortification 

Dr. Mehta is also the principal investigator of a randomized controlled trial of biofortified pearl millet (high iron and zinc) designed to examine the effects of its consumption on growth and immune and cognitive function among 700 infants in India. This trial is currently scheduled to start in mid-2014. 

 

Novel Diagnostics 

In collaboration with the Erickson lab, Dr. Mehta is involved in the development of novel smartphone-based assays for diagnosis of infectious diseases and nutritional deficiencies. In work supported by the Atkinson Center for a Sustainable Future, a prototype for detecting vitamin D status through the measurement of serum 25-hydroxyvitamin D concentrations has been developed recently. The aim is to extend the capability of this platform to detect the status of multiple micronutrients simultaneously ('multiplex') with a minimal amount of blood and at a low cost. While such devices can help with personalized monitoring of nutritional status in the resource-rich context, they can massively improve health services in poorer settings. Most primary health care centers, for example, in developing countries don't have access to conventional assays for nutritional status as they need sophisticated laboratory setups and trained personnel. Equipping such health care centers with a smartphone-based device, which can be easily interpreted by a health worker, can immediately upgrade the quality of service and access for the thousands of individuals served by each center. Ongoing work is also focusing on developing a rapid diagnostic assay for Dengue, the fastest growing vector-borne viral infection in the world. 

 

Surveillance 

The Mehta research group is also helping setup active surveillance systems for infectious diseases such as Dengue and Tuberculosis in Ecuador and India. The aims include using epidemiologic tools to conduct surveillance for early detection of these diseases, expand surveillance and epidemiology training and capacity in partner countries, and increase research in identifying nutritional and immunological risk factors for these diseases. 

 
Education:

M.B.B.S. - All India Institute of Medical Sciences, New Delhi, India - 2003 

M.S. (Epidemiology) - Harvard University, Cambridge MA - 2004 

Sc.D. (Epidemiology and Nutrition) - Harvard University, Cambridge MA - 2009 

 
Courses Taught:

NS 3060 - Nutrition and Global Health 

NS 6580 - Advanced Epidemiology: Theory and Practice 

 

Guest Lectures 

NS 1220 - Nutrition and the Life Cycle 
Session on Health and Nutrition Disparities: A Global Perspective 

NS 6200 - Translational Research and Evidence-based Policy and Practice in Nutrition 
Sessions on International Harmonization of Evidence-based Policy and Practice: Difference and Similarities and Statistical Approaches to Synthesis of Data 

 
Related Websites:

mehta.human.cornell.edu 

 
Administrative Responsibilities:

Member, DNS Curriculum Committee 

Member, Field of Nutrition Seminar Committee 

Member, Mann Library Working Group 

Member, DNS Admissions Committee  

 
Selected Publications:

 

Peer-Reviewed Journal Articles  

1. Sohal DPS, Garg N, Singh D, Mehta S, Anand K, Kapoor SK. Antibiotic prescription practice at primary and secondary level hospitals of a medical college. Indian Practitioner 2006;59(12):789-94. 
 
2. Mehta S, Fawzi W. Effects of Vitamins, Including Vitamin A, on HIV/AIDS Patients. Vitam Horm 2007; 75: 355-383. 
 
3. Mehta S, Ding EL, Fawzi WW, Giovannucci EL. Influence of Estrogen Therapy on Effects of Calcium and Vitamin D for Colorectal Cancer Prevention. Int J Cancer 2008;122:1690-4. 
 
4. Wig N, Sakhuja A, Agarwal SK, Khakha DC, Mehta S, Vajpayee M. Multidimensional health status of HIV-infected outpatients at a tertiary care center in north India. Indian J Med Sci 2008;62:87-97. 
 
5. Mehta S, Manji KP, Young AM, Brown ER, Chasela CC, Taha TE, Read JS, Goldenberg RL, Fawzi, WW. Nutritional indicators of adverse pregnancy outcomes and mother-to-child transmission of HIV among HIV-infected women. Am J Clin Nutr 2008;87:1639-49. PMCID: PMC2474657 
 
6. Shet A, Mehta S, Rajagopalan N, Dinakar C, Ramesh E, Samuel NM, Indumathi CK, Fawzi WW, Kurpad AV. Anemia and growth failure among HIV-infected children in India: a retrospective analysis. BMC Pediatr 2009;9:37. PMCID: PMC2702283 
 
7. Mehta S, Hunter DJ, Mugusi FM, Spiegelman D, Manji KP, Giovannucci EL, Hertzmark E, Msamanga GI, Fawzi WW. Perinatal Outcomes, Including Mother-to-Child Transmission of HIV, and Child Mortality, and Their Association with Maternal Vitamin D Status in Tanzania. J Inf Dis 2009;200:1022-1030. Accompanied by an Editorial Commentary: Spector SA. Vitamin D Earns More Than a Passing Grade. J Inf Dis 2009;200:1015-1017. PMCID: PMC2758703 
 
8. Mugusi FM, Mehta S, Villamor EV, Urassa W, Saathoff E, Bosch RJ, Fawzi WW. Factors associated with mortality in HIV-infected and uninfected patients with pulmonary tuberculosis. BMC Public Health 2009;9:409. PMCID: PMC2779816 
 
9. Franke MF, Spiegelman D, Ezeamama A, Aboud S, Msamanga GI, Mehta S, Fawzi WW. Malaria Parasitemia and CD4 T-cell count, Viral Load, and Adverse HIV Outcomes among HIV-infected Pregnant Women in Tanzania. Am J Trop Med Hyg 2010;82:556-562. PMCID: PMC2844563 
 
10. Mehta S, Giovannucci E, Mugusi FM, Spiegelman D, Aboud S, Hertzmark E, Msamanga GI, Hunter D, Fawzi WW. Vitamin D status of HIV-infected women and its association with HIV disease progression, anemia, and mortality. PLoS One 2010;5:e8770. PMCID: PMC2808247 
 
11. Mehta S, Spiegelman D, Aboud S, Giovannucci EL, Msamanga GI, Hertzmark E, Mugusi FM, Hunter DJ, Fawzi WW. Lipid-soluble vitamins A, D, and E in HIV-infected pregnant women in Tanzania. Eur J Clin Nutr.2010;64:808-17. PMCID: PMC3078753 
 
12. Mehta S, Fawzi WW. Editorial Commentary: Micronutrient Supplementation as Adjunct Treatment in HIV-infected Patients. Clin Inf Dis. 2010;50:1661-1663. 
 
13. Liu E, Spiegelman D, Semu H, Hawkins C, Chalamilla G, Aveika A, Nyamsangia S, Mehta S, Mtasiwa D, Fawzi WW. Nutritional Status and Mortality Among HIV-infected Patients Receiving Antiretroviral Therapy in Tanzania. J Infect Dis 2011; 204:282-90. 
 
14. Murray CJ, Lopez AD, Black R, Ahuja R, Mohd Ali S, Baqui A, Dandona L, Dantzer E, Das V, Dhingra U, Dutta A, Fawzi W, Flaxman AD, Gomez S, Hernandez B, Joshi R, Kalter H, Kumar A, Kumar V, Lozano R, Lucero M, Mehta S, Neal B, Ohno SL, Prasad R, Praveen D, Premji Z, Ramirez-Villalobos D, Remolador H, Riley I, Romero M, Said M, Sanvictores D, Sazawal S, Tallo V. Population Health Metrics Research Consortium Gold Standard Verbal Autopsy Validation Study: Design, Implementation and Development of Analysis Datasets. Popul Health Metr 2011;9:27. PMCID: PMC3160920 
 
15. Mehta S, Mugusi FM, Spiegelman D, Villamor E, Finkelstein JL, Hertzmark E, Giovannucci EL, Msamanga GI, Fawzi WW. Vitamin D Status and its Association with Morbidity including Wasting and Opportunistic Illnesses in HIV-infected Women in Tanzania. AIDS Patient Care STDs 2011;25:579-585. PMCID: PMC3183700 
 
16. Mehta S, Mugusi FM, Bosch RJ, Aboud S, Chatterjee A, Finkelstein JL, Fataki M, Kisenge R, Fawzi WW. A Randomized Trial of Multivitamin Supplementation in Children with Tuberculosis in Tanzania. Nutr J 2011;10:120. PMCID: PMC3229564 
 
17. Finkelstein JL, Mehta S, Aboud S, Duggan CP, Kupka R, Spiegelman D, Msamanga GI, Fawzi WW. Predictors of Anemia and Iron Deficiency in HIV-infected Pregnant Women: A potential role for vitamin D and parasitic infections. Public Health Nutr 2012;15:928-937. PMCID: PMC3366262 
 
18. Shet A, Arumugam K, Rajagopalan N, Dinakar C, Krishnamurthy S, Mehta S, Shet AS. The prevalence and etiology of anemia among HIV-infected children in India. Eur J Pediatr. 2012;171:531-540. PMID: 22009132 
 
19. Finkelstein JL, Mehta S, Duggan CP, Manji KP, Spiegelman D, Msamanga GI, Fawzi WW. Maternal Vitamin D Status and Child Morbidity, Anemia, and Growth in Human Immunodeficiency Virus-exposed Children in Tanzania. Pediatr Infect Dis J 2012;31:171-175. PMCID: PMC3813463 
 
20. Finkelstein JL, Manji KP, Duggan C, Hertzmark E, Mehta S, Msamanga GI, Spiegelman D, Fawzi WW. Predictors of incident tuberculosis in HIV-exposed children in Tanzania. East Afr Med J 2012;89:183-192. 
 
21. Hawkins C, Christian B, Ye J, Nagu T, Aris E, Chalamilla G, Spiegelman D, Mugusi F, Mehta S, Fawzi W. Prevalence of Hepatitis B co-infection and response to antiretroviral therapy among HIV-infected patients in urban Tanzania. AIDS 2013;27:919-27. PMID: 23196935 
 
22. Fataki M, Kisenge RR, Sudfeld CR, Aboud S, Okuma J, Mehta S, Spiegelman D, Fawzi WW. Effect of Zinc Supplementation on Duration of Hospitalization in Tanzanian Children Presenting with Acute Pneumonia. J Trop Pediatr 2013 Nov 5. [Epub ahead of print] PMID: 24194421 
 
23. Mehta S, Mugusi FM, Bosch RJ, Aboud S, Urassa W, Villamor E, Fawzi WW. Vitamin D status and TB treatment outcomes in adult patients in Tanzania. BMJ Open 2013;3:e003703. PMCID: PMC3840339 
 
24. Murray CJ, Lozano R, Flaxman AD, Serina P, Phillips D, Stewart A, James SL, Vahdatpour A, Atkinson C, Freeman MK, Ohno SL, Black R, Ali SM, Baqui AH, Dandona L, Dantzer E, Darmstadt GL, Das V, Dhingra U, Dutta A, Fawzi W, Gómez S, Hernández B, Joshi R, Kalter HD, Kumar A, Kumar V, Lucero M, Mehta S, Neal B, Praveen D, Premji Z, Ramírez-Villalobos D, Remolador H, Riley I, Romero M, Said M, Sanvictores D, Sazawal S, Tallo V, Lopez AD. Using Verbal Autopsy to Measure Causes of Death: The Comparative Performance of Existing Methods. BMC Med 2014;12:5. PMCID: PMC3891983 
 
25. Ahmed S, Finkelstein JL, Stewart AM, Kenneth J, Polhemus ME, Endy TP, Mehta S. Micronutrients and Dengue: A Review of the Current Evidence. In review. 
 
26. Lee S, Oncescu V, Mancuso M, Mehta S, Erickson D. A smartphone platform for the quantification of vitamin D levels. In review. 
 
27. Erickson D, O’Dell D, Jiang L, Oncescu V, Mancuso M, Mehta S. Smartphones will be transformative for the deployment of lab-on-a-chip devices. Lab Chip. Invited Opinion. 
 
Invited Book 
1. Mehta S, Finkelstein JL, eds. Nutrition and HIV: From Epidemiological Evidence to Public Health. CRC Press. In preparation
 
Book Chapters and Technical Papers 
1. Mehta S, Finkelstein JL, Fawzi WW. Nutritional Interventions in HIV-Infected Breastfeeding Women. Ann Nestlé [Engl] 2007; 65: 39–48. 
 
2. Mehta S, Fawzi WW. Hunger and HIV and Tuberculosis. Technical paper for the World Hunger Series 2007. World Food Programme, Rome, Italy. 
 
3. Mehta S, Finkelstein JL, Fawzi WW. Micronutrient status and pregnancy outcomes in HIV-infected women. Editors: Lammi-Keefe CJ, Couch SC, Philipson, E. Humana Press: Baton Rouge, LA. Handbook of Nutrition and Pregnancy 2008; 23: 355-365. 
 
4. Finkelstein JL, Mugusi FM, Mehta S, Fawzi WW. HIV/AIDS and Nutrition in the HAART Era: Programmatic implications for HIV/AIDS care and treatment in resource-limited settings. Editors: Marlink RG, Teitelman SJ. Elizabeth Glaser Pediatric AIDS Foundation: Washington, DC. From the Ground Up: Building Comprehensive HIV/AIDS Care in Resource-Limited Settings 2009. 
 
5. Yu EA, Finkelstein JL, Mehta S. HIV and Micronutrients. Editors: Pammi M, Vallejo JG, Abrams SA. Taylor and Francis Books, Inc.: Boca Raton, FL. Nutrition-Infection Interactions and Impacts on Human Health. In press.
 
Letters to the Editor 
1. Mehta S, Fawzi WW. Letter to the Editor in response to comments on: Mehta S, et al. Perinatal Outcomes, Including Mother-to-Child Transmission of HIV, and Child Mortality, and Their Association with Maternal Vitamin D Status in Tanzania. J Inf Dis. 2010;201:1951. 
 
2. Finkelstein JL, Mehta S, Fawzi WW. Letter to the Editor in response to comments on: Finkelstein JL, et al. Predictors of Anemia and Iron Deficiency in HIV-infected Pregnant Women: A potential role for vitamin D and parasitic infections. Public Health Nutr 2012;20:1. [Epub ahead of print]. 

 

 
Searchable Keywords:

Global Health, Nutrition, Epidemiology, Maternal and Child Health, Infectious Diseases, HIV/AIDS, Tuberculosis, Malaria, Africa, Tanzania, South Asia, India, Micronutrients, Multivitamins, Vitamin D

 
The information on this bio page is taken from the CHE Annual Report.