Patrick Stover

 

Patrick Stover

Professor & Division Director
127 Savage Hall
 
Phone: (607) 255-8001
Email: pjs13@cornell.edu
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Curriculum Vitae
 
Biographical Statement:

Patrick J. Stover, Ph.D. is Professor and Director of the Division of Nutritional Sciences at Cornell University.  He graduated from Saint Joseph’s University with a BS degree in Chemistry and was awarded the Molloy Chemistry Award at graduation.  He received a PhD degree in Biochemistry and Molecular Biophysics from the Medical College of Virginia and performed his postdoctoral studies in Nutritional Sciences at the University of California at Berkeley.

The Stover research group investigates the chemical, biochemical, genetic and epigenetic mechanisms that underlie the relationships between one-carbon metabolism and human pathologies including neural tube defects, cardiovascular disease and cancer.  Specific interests include the regulation of folate-mediated one-carbon metabolism and genome expression and stability, the molecular basis of the fetal origins hypothesis, development of mouse models to elucidate mechanisms of folate-related pathologies, and translational control of gene expression. Our current focus is on the role of nuclear one-carbon metabolism in de novo thymidylate synthesis in maintaining genome integrity, and its regulation by SUMOylation.  We have developed mouse models of altered one-carbon metabolism by gentically manipulating the expression of folate-associated genes to determine the effects of altered one-carbon supply on cellular methylation potential, nucleotide biosynthesis and colon cancer susceptibility. An overarching goal of these studies is to differentiate the contributions of folate-dependent de novo nucleotide biosynthesis and folate-mediated cellular methylation in folate-associated pathologies. Patrick Stover also teaches two classes for graduate students: NS7040, Grant Writing and NS6200 Translational Research and Evidence-based Policy and Practice in Nutrition.

Patrick Stover received a MERIT award in 2012 from NIDDK-NIH.  In 1996 he received the Presidential Early Career Award for Scientists and Engineers from President Clinton, the highest honor bestowed by the U.S. government on outstanding scientists and engineers beginning their independent careers. He received the ERL Stokstad Award in Nutritional Biochemistry from the American Society for Nutritional Sciences in 1999 and has been selected as an Outstanding Educator four times by Cornell Merrill Presidential Scholars.  He is a current member of the National Academies of Sciences’ Food and Nutrition Board.  He serves on the editorial board for the Annual Reviews of Nutrition, the Journal of Biological Chemistry and the American Journal of Clinical Nutrition.

 
Current Professional Activities:

Director, Division of Nutritional Sciences

Vice President, American Society for Nutrition

Director,  United Nations University Food and Nutrition Programme for Social Development

Cornell University Graduate Field Membership: Nutrition, Biochemistry, Molecular and Cellular Biology

Editorial Boards: Annual Review of Nutrition, The American Journal of Clinical Nutrition, The Journal of Biological Chemistry

 
Current Research Activities:

Regulation of folate-mediated one-carbon metabolism; Metabolic regulation of genome methylation and stability; Folate-genome interactions in colon cancer and developmental anomalies; Nuclear folate metabolism; Role and regulation of uracil in DNA.

 
Current Extension Activities:

The Director of the Division of Nutritional Sciences provides oversight of DNS extension activities.

 
Education:

PhD     1990    Medical College of Virginia, Biochemistry and Molecular Biophysics
BS        1986    Saint Joseph's University, Chemistry

 
Courses Taught:
  • BioG 2000     Research Apprenticeship

  • BioBM 4000  Undergraduate Research

  • NS 3200         Human Biochemistry

  • NS 4000         Directed Readings

  • NS 4010         Student Research

  • NS 6200         Translational Reserach and Evidence-based Policy and Practice in Nutrition

  • NS 7040         Grant Writing

 

 
Related Websites:

DNS Home Page; United Nations University; www.linkedin.com/profile/edit

 
Administrative Responsibilities:

Director, Division of Nutritional Sciences

Director, United Nations University Food and Nutrition Programme for Human and Social Development

 

 
Selected Publications:

MacFarlane, A.J., Perry, C.A., McEntee, M.F., Lin, D.M., and Stover, P.J. 2014 Azoxymethane-induced colon carcinogenesis in mice occurs independently of de novo thymidylate synthesis capacity. J. Nutr. In press

Ash JA, Jiang X, Malysheva OV, Fiorenza CG, Bisogni AJ, Levitsky DA, Strawderman MS,  Caudill MA, Stover PJ, Strupp BJ.  2013. Dietary and genetic manipulations of folate metabolism differentially affect prefrontal cortical functions in mice.  Neurotoxicology and Teratology, 38:79-91. PMID: 23684804

Abarinov, E.V., Beaudin, A.E., Field, M.S., Perry, C., Allen, R., Stabler, S., Stover, P.J. 2013. Disruption of Shmt1 impairs hippocampal neurogenesis and mnemonic function in mice. J. Nutr. 143(7):1028-35. PMC3681542

Scotti M., Stella L., Shearer E.J., Stover P.J. 2013. Modeling cellular compartmentation in one-carbon metabolism. Wiley Interdiscip Rev Syst Biol Med. 5(3):343-65 PMID: 23408533

Field, M.S., Shields, K.S., Abarinov, E., Malysheva, O.V., Allen, R.H., Stabler, S.P., Ash, J.A., Strupp, B.J., Stover, P.J., Caudill, M.A. 2013. Reduced MTHFD1 activity in male mice perturbs folate and choline dependent one-carbon metabolism as well as transsulfuration. J. Nutr. 143(1):41-5.  PMC: 3521460

Ohlhorst, S., Russell, R., Bier, D., Klurfeld, D., Li, Z., Mein, J., Milner, J.A., Ross, C., Stover, P., Konopka, E.  2013. Nutrition Research to impact food and a healthy lifespan. Adv Nutr. 4(5):579-84.

Ohlhorst, S., Russell, R., Bier, D., Klurfeld, D., Li, Z., Mein, J., Milner, J.A., Ross, C., Stover, P., Konopka, E.  2013. Nutrition Research to impact food and a healthy lifespan. J Nutr. 143(8):1349-54. 

Ohlhorst, S., Russell, R., Bier, D., Klurfeld, D., Li, Z., Mein, J., Milner, J.A., Ross, C., Stover, P., Konopka, E.  2013. Nutrition Research to impact food and a healthy lifespan. Am J Clin Nutr. 98(2):620-5. 

Stover, P.J. 2013.  Nutrient-Genome Interactions.  In Handbook of Vitamins, Fifth Edition. Chapter 16. (Janos, Stover, Gregory, eds). Taylor and Francis Group, LLC.

Hobin, J.A., Deschamps, A.M., Bockman, R., Cohen, S., Dechow, P., Eng, C., Galey, W., Morris, M., Prabhakar, S., Raj, U., Rubenstein, P., Smith, J.A., Stover, P., Sung, N., Talman, W., Galbraith, R. 2012. Engaging basic scientists in translational research: identifying opportunities, overcoming obstacles. J Transl Med. 10(1):72. PMC:  3419626

Delisle H. 2012. Empowering our profession in Africa.  World Nutrition 3 (6): 269-284 co-signatory

Stover, P.J., Weiss, R.S. Sensitizing cancer cells: is it really all about U? Cancer Cell. 2012 Jul 10;22(1):3-4. PMID: 22789532

Romagnolo, D.F., Dashwood, R., Stover, P.J., Waterland, R.A., Ziegler, T.R. 2012.  Nutritional regulation of epigenetic changes.  Adv Nutr. 3(5):749-50. PMID: 22983864

Gu, Z., Ye, K., Stover, P.J.  2012.  Nutritional Genomics.  In Genomics and Clinical Medicine, Chapter 8, edited by Dhavendra Kumar, Oxford University Press.

Stover, P. J.  2012.  Genetic Variation: Effect of Nutrient Utilization and Metabolism. In Modern Nutrition in Health and Disease, 11th Edition. (C. Ross, ed.) 523-533.

Stover, P. J.  2012.  Folic Acid in Modern Nutrition in Health and Disease, 11th Edition. (C. Ross, ed.) 358-368.

Swayne, B.G., Behan, N.A., Williams, A., Stover, P.J., Yauk, C.L., MacFarlane, A.J. 2012. Supplemental dietary folic acid has no effect on chromosome damage in erythrocyte progenitor cells of mice. J Nutr.142(5):813-7. PMC3735919

Wernimont, S.M., Clark, A.G., Stover, P.J., Wells, M.T., Litonjua, A.A., Weiss, S.T., Gaziano, J.M., Vokonas, P.S., Tucker, K.L., Cassano, P.A. 2012. Folate Network Genetic Variation Predicts Cardiovascular Disease Risk in Non-Hispanic White Males. J. Nutr. 142(7):1272-9 PMC:  3374665

Beaudin, A.E., Perry, C.A., Stabler, S.P., Allen, R.H., and Stover, P.J. 2012. Maternal Mthfd1 disruption impairs fetal growth but does not cause NTDs in mice.  Amer. J. Clin Nutr. 95(4):882-91.  PMC:  3302363

Anderson, D.D., Woeller, C.F., Chiang, E-P., Shane, B., and Stover, P.J.  2012. SHMT1 and SHMT2 anchor the nuclear de novo thymidylate synthesis pathway to the nuclear lamina for DNA replication and repair.  J. Biol. Chem. 287(10):7051-62. PMC:  3293584

Beaudin, A.E., Abarinov, E.V., Malysheva, O., Perry, C.A., Caudill, M., and Stover, P.J. 2012. Dietary folate but not choline modifies neural tube defect risk in Shmt1 knock-out mice.  Amer. J. Clin. Nutr. 95(1):109-14.  PMC:  3238454

Stover, P. J.  2012.  Folic acid and neural tube defects: Are we any closer to understanding mechanisms?  Clinical Correlation in Biochemical, Physiological, Molecular Aspects of Human Nutrition, 3rd edition.

Stover, P. J.  2011.  Polymorphisms in 1-carbon metabolism, epigenetics and folate-related pathologies. J. Nutrigenet. Nutrigenomics 4:293-305.

Yetley, E.A., Pfeiffer, C.M., Phinney, K.W., Fazili, K., Lacher, D.A., Bailey, R.L., Blackmore, S.,  Bock, J.L., Brody, L.C., Carmel, R., Curtin, L.R., Durazo-Arvizu, R.S., Eckfeldt, J.H., Green, R., Gregory III, J.F., Hoofnagle, A.N., Jacobsen, D.W., Jacques, P.F., Molloy, A.M., Massaro, J., Mills, J.L., Nexo, E., Rader, J.I., Selhub, J., Sempos, C., Shane, B., Stabler, S., Stover, P., Tamura, T., Tedstone, A., Thorpe, S.J., Coates, P.M., Johnson, C.L., and Picciano, M.F.  2011.    Biomarkers of folate status in the National Health and Nutrition Examination Survey (NHANES): a roundtable summary.  Am J. Clin. Nutr. 94(1):303S-312S.  PMC: 3127517

Yetley, E.A., Pfeiffer, C.M., Phinney, K.W., Bailey, R.L., Blackmore, S., Bock, J.L., Brody, L.C., Carmel, R., Curtin, L.R., Durazo-Arvizu, R.S., Eckfeldt, J.H., Green, R., Gregory III, J.F., Hoofnagle, A.N., Jacobsen, D.W., Jacques, P.F., Lacher, D.A., Molloy, A.M., Massaro, J., Mills, J.L., Nexo, E., Rader, J.I., Selhub, J., Sempos, C., Shane, B., Stabler, S., Stover, P., Tamura, T., Tedstone, A., Thorpe, S.J., Coates, P.M., Johnson, C.L., and Picciano, M.F.  2011.    Biomarkers of vitamin B-12 status in the National Health and Nutrition Examination Survey (NHANES): a roundtable summary.  Am J. Clin. Nutr. 94(1):313S-321S.  PMC: 3127527

Anderson, D.D., Eom, J.Y., and Stover, P.J. 2011. Competition between sumoylation and ubiquitylation of serine Hydroxymethyltransferase 1 determines its nuclear localization and its accumulation in the nucleus. J. Biol. Chem. 287(7):4790-9.  PMC:  3281627

Wernimont, S.M., Clark, A.G., Stover, P.J., Wells, M.T., Litonjua, A.A., Weiss, S.T., Gaziano, J.M., Tucker, K.L., Baccarelli, A., Schwartz, J., Bollati, V., and Cassano, P.A. 2011. Folate network genetic variation, plasma homocysteine, and global genomic methylation content: a genetic association study. BMC Med Genet. Nov 21;12(1):150. PMC:  3266217

MacFarlane, A.J., Anderson, D.D., Flodby, P., Perry, C.A., Allen, R.A., Stabler, S.P, and Stover, P.J.  2011. Nuclear localization of the de novo thymidylate biosynthesis pathway is required to prevent uracil accumulation in DNA.  J. Biol. Chem. 286(51):44015-22. PMC:  3243516

Anderson, D.D., Quintero, C.M., and Stover, P.J. 2011. Identification of a de novo thymidylate biosynthesis pathway in mammalian mitochondria. Proc. Natl. Acad. Sci. 108(37):15163-8. PMC:  3174652

Field, M.S., Anderson, D.D., and Stover, P.J. 2011. Mthfs is an essential gene in mice and a component of the purinosome.  Front. Gene. 2:36.

Beaudin, A.E., Abarinov, E.V., Noden, D.M., Perry, C.A., Chu, S., Stabler, S.P., Allen, R.H., and Stover, P. J. 2011. Shmt1 and de novo thymidylate biosynthesis underlie folate-responsive neural tube defects in mice.  Am. J. Clin. Nutr. 93(4):789-98. PMC:  3057548

MacFarlane, A.J., Perry, C.A., McEntee, M.F., Lin, D.M., and Stover, P.J. 2011.  Mthfd1 is a Modifier of Chemically-induced Intestinal Carcinogenesis.  Carcinogenesis 32(3):427-33.

PMC:  3047240

 

Wernimont, S.M., Raiszadeh, F., Stover, P.J., Rimm, E., Hunter, D., Tang, W., and Cassano, P.A.  2011.  Polymorphisms in Serine Hydroxymethyltransferase 1 and Methylenetetrahydro-folate Reductase Interact to Increase Cardiovascular Disease Risk in Humans.  J Nutr. 141(2):255-60. PMC:  3021444

MacFarlane, A.J., Perry, C.A., McEntee, MF., Lin, D.M., and Stover, P.J.  2011 Shmt1 Heterozygosity Impairs Folate-Dependent Thymidylate Synthesis Capacity and Modifies Risk of Apcmin-Mediated Intestinal Cancer Risk.  Can Res. 71(6):2098-107. PMC:  3059437

Ching, Y-H.,  Munroe, R.J., Moran, J.L., Barker, A.K., Mauceli, E., Fennell, T., diPalma, F., Lindblad-Toh, K., Abcunas, Abuncas, L.M., Gilmour, J.F., Harris, T.P., Kloet, S.L., Luo, Y., McElwee, J., Mu, W., Park, H.K., Rogal, D.L., Schimenti, K.J.,  Shen, L., Shindo, M., Shou, J.Y.,  Stenson, E.K., Stover, P.J., and Schimenti, J.C. 2010. High Resolution Mapping and Positional Cloning of ENU-induced Mutations in the Rw region of Mouse Chromosome 5.  BMC Genet. 11(1):106. PMC:  3009607

Stover, P.J., Harlan, W.R., Hammond, J.A., Hendershot, T., and Hamilton, C.M. 2010.  PhenX: An Interdisciplinary Toolkit for Genetics and Epidemiology.  Curr. Opin. Lipidol. 21(2):136-40. PMID: 20154612

Bentley, A.R., Raiszadeh, F., Stover, P.J., Hunter, D.J., Hankinson, S.E., and Cassano, P.A. 2010. No association between cSHMT genotypes and the risk of breast cancer in the Nurses' Health Study.  Eur. J. Clin. Nutr.  64(1):108-10. PMC:  3033771

 
Searchable Keywords:
One-carbon metabolism
Nutrition
Biochemsitry
Folate
Birth defects
Cancer
Nucleotide Biosynthesis

 
The information on this bio page is taken from the CHE Annual Report.