Paul Soloway


Paul Soloway

211 Weill Hall
Phone: (607) 254-6444 Fax: 607-255-1366
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Curriculum Vitae
Biographical Statement:

Formal education includes a BA 1979 from Cornell University in Biology and a PhD 1989 from Princeton University in Molecular Biology. Post doctoral training was at MIT and the Whitehead Institute from 1998-1994. Independent positions as a Principal Investigator were at Roswell Park Cancer Institute from 1994-2002 and at Cornell University from 2002 to the present. Area of expertise is mouse molecular genetics, mechanisms controlling placement of epigenetic modifications including DNA and histone methylation in the mouse genome and technology development for genome wide single molecule epigenetic profiling. 

Teaching and Advising Statement:

It is an honor and a privilege to be teacher and advisor to the enthusiastic, creative and intelligent minds who come to Cornell for study.  I strive to serve their educational goals with the commitment I would extend to my own children.  Each student has their own unique needs, and I tailor my approach to meet them.  I bring this philosophy into my classroom, my research lab, and when I meet individually with students, not just for their benefit, but for my own as well.  When I execute my responsibilities guided by this philosophy, I feel like the teacher, advisor, scientist and human I wish to be.  

Current Professional Activities:

Research:  50%
Teaching:  50%

Current Research Activities:

Current research activities are in the area of epigenetics and includes several separate sets of projects.  One of these seeks to characterize the mechanisms regulating the epigenetic phenomena of DNA and histone methylation in mice using the Rasgrf1 gene as a model.  These methylation events are potent regulators of gene expression and respond to environmental variables, including nutrition, in ways that are stable and inheritable.  A second set of projects seeks to identify how different histone and DNA methylation events are coordinated, either positively or negatively in the genome.  A third set of projects seeks to develop next generation methods for single molecule profiling of multiple epigenetic states, simultaneously and genome wide.  A fourth and new project is a new collaboration with Prof. Barbara Strupp to characterize epigenomic mechanisms by which maternal choline supplementation leads to improved cognitive outcomes in the progeny.  Recent advances in epigenomic methods make this project tractable.  


Post-doc 1994 - Whitehead Institute / MIT, Molecular Genetics - Advisor, R. Jaenisch
Ph.D. 1989 - Princeton University, Molecular Genetics - Advisor, T. Shenk
BA 1979 - Cornell University, Biochemistry

Courses Taught:

NS 4900 - Manipulating the Mouse Genome

NS 6080 - Epigenetics

Related Websites:

Lab Site:

Administrative Responsibilities:

Co-Chair, University Hearing Board 

Selected Publications:

Click here for a link to publications listed in Pubmed

Publications Jan 1, 2013-Dec 31, 2013:

  1. Soloway, A.H., P.D. Soloway, and V.D. Warner, Chemical Initiators of Cognitive Dysfunction in Phenylketonuria. Med Hypotheses, 2013. 81: 690–694.
  2. Murphy, P.J., B.R. Cipriany, C.M. Wallin, K. Szeto, J.J. Benitez, H.G. Craighead, and P.D. Soloway, Single-molecule Analysis of Combinatorial Epigenomic States in Normal and Tumor Cells. Proc Natl Acad Sci U S A, 2013. 110(19): 7772.
  3. Hagarman, J.A., M.P. Motley, K. Kristjansdottir, and P.D. Soloway, Coordinate regulation of DNA methylation and H3K27me3 in mouse embryonic stem cells. PLoS One, 2013. 8(1): p. e53880.
  4. Hagarman, J.A. and P.D. Soloway, Epigenomics - One molecule at a time. Cell Cycle, 2013. 12 p. 1-2..

Searchable Keywords:
Mouse molecular genetics

The information on this bio page is taken from the CHE Annual Report.