Mazor KM, Stipanuk MH (2016) GCN2- and eIF2α-phosphorylation-independent, but ATF4-dependent, induction of CARE-containing genes in methionine-deficient cells. Amino Acids 48:2831-2842.
Driggers CM, Kean KM, Hirschberger LL, Cooley RB, Stipanuk MH, Karplus PA (2016) Structure-Based Insights into the Role of the Cys-Tyr Crosslink and Inhibitor Recognition by Mammalian Cysteine Dioxygenase. J Mol Biol 428:3999-4012.
Niewiadomski J, Zhou JQ, Roman HB, Liu X, Hirschberger LL, Locasale JW, Stipanuk MH (2016) Effects of a block in cysteine catabolism on energy balance and fat metabolism in mice. Ann N Y Acad Sci 1363:99-115.
Jurkowska H, Niewiadomski J, Hirschberger LL, Roman HB, Mazor KM, Liu X, Locasale JW, Park E, Stipanuk MH (2016) Downregulation of hepatic betaine:homocysteine methyltransferase (BHMT) expression in taurine-deficient mice is reversed by taurine supplementation in vivo. Amino Acids 48:665-676.
Jurkowska H., Roman H.B., Hirschberger L.L., Sasakura K., Nagano T., Hanaoka K., Krijt J., Stipanuk M.H. (2014) Primary hepatocytes from mice lacking cysteine dioxygenase show increased cysteine concentrations and higher rates of metabolism of cysteine to hydrogen sulfide and thiosulfate. Amino Acids 46:1353-1365.
Sikalidis A.K., Mazor K.M., Lee J.I., Roman H.B., Hirschberger L.L., Stipanuk M.H. (2014) Upregulation of capacity for glutathione synthesis in response to amino acid deprivation: regulation of glutamate-cysteine ligase subunits. Amino Acids 46:1285-1296.
Driggers C.M., Cooley R.B., Sankaran B., Hirschberger L.L., Stipanuk M.H., and Karplus P.A. (2013) Cysteine dioxygenase structures from pH4 to 9: consistent cys-persulfenate formation at intermediate pH and a Cys-bound enzyme at higher pH. J Mol Biol. 425:3121-3136.
Roman H.B., Hirschberger L.L., Krijt J., Valli A., Kožich V., and Stipanuk M.H. (2013) The cysteine dioxgenase knockout mouse: altered cysteine metabolism in nonhepatic tissues leads to excess H2S/HS- production and evidence of pancreatic and lung toxicity. Antioxid Redox Signal. 19:1321-1336.
Ueki, I., Roman, H.B., Hirschberger, L.L., Junior, C., and Stipanuk, M.H. (2012) Extrahepatic tissues compensate for loss of hepatic taurine synthesis in mice with liver-specific knockout of cysteine dioxygenase. Am J Physiol Endocrinol Metab. 302:E1292-E1299.
Ueki, I., Roman, H.B., Valli, A., Fieselmann, K., Lam, J., Peters, R., Hirschberger, L.L., and Stipanuk, M.H. (2011) Knockout of the cysteine dioxygenase gene results in severe impairment in taurine synthesis and increased catabolism of cysteine to hydrogen sulfide. Am J Physiol Endocrinol Metab. 301: E688-E684.
Stipanuk M.H. and Ueki, I. (2011) Dealing with methionine/homocysteine sulfur: cysteine metabolism to taurine and inorganic sulfur. J Inherit Metab Dis. 34:17-32.
Stipanuk MH, Simmons CR, Karplus PA, Dominy JE Jr. (2011) Thiol dioxygenases: unique families of cupin proteins. Amino Acids 41:91-102.
Stipanuk, M.H., Ueki, I., Dominy, J.E. Jr., Simmons, C.R., and Hirschberger, L.L. (2009) Cysteine dioxygenase: a robust system for regulation of cellular cysteine levels. Amino Acids 37:55-63.
Simmons, C.R., Krishnamoorthy, K., Granett, S.L., Schuller, D.J., Dominy, J.E. Jr., Begley, T.P., Stipanuk, M.H., and Karplus, P.A. (2008) A putative Fe2+-bound persulfenate intermediate in cysteine dioxygenase. Biochemistry 47:11390-11392.
Dominy, J.E. Jr., Hwang, J., Guo, S., Hirschberger, L.L., Zhang, S., and Stipanuk, M.H. (2008) Synthesis of amino acid cofactor in cysteine dioxygenase is regulated by substrate and represents a novel post-translational regulation of activity. J. Biol. Chem. 283:12188-12201.
Lee, J-I., Dominy, J.E., Jr., Sikalidis, A. K., Hirschberger, L.L., Wang,W., and Stipanuk, M.H. (2008) HepG2/C3A cells respond to cysteine-deprivation by induction of the amino acid deprivation/integrated stress response pathway. Physiol. Genomics 33:218-229.
Dominy,J. E. Jr., Simmons, C.R., Hirschberger, L.L., Hwang, J., Coloso, R.M., Stipanuk, M.H. (2007) Discovery and characterization of a second mammalian thiol dioxygenase: Cysteamine dioxygenase. J. Biol. Chem. 282:25189-25198.
Dominy, J.E. Jr., Simmons, C.R., Karplus, P.A., Gehring, A.M., and Stipanuk, M.H. (2006) Identification and characterization of bacterial cysteine dioxygenases: a new route of cysteine degradation for eubacteria. J. Bacteriol. 188:5561-5569.
Simmons,C.R., Liu, Q., Huang, Q., Hao, Q., Begley, T.P., Karplus, P.A., and Stipanuk, M.H. (2006) Crystal structure of mammalian cysteine dioxygenase: A novel mononuclear iron center for cysteine thiol oxidation. J. Biol. Chem. 281:18723-18733. [Issue cover is CDO structure].
Dominy, J.E., Hirschberger, L.L., Coloso, R. M., and Stipanuk, M.H. (2006) Regulation of cysteine dioxygenase degradation is mediated by intracellular cysteine levels and the ubiquitin-26S proteasome system in the living rat. Biochem. J. 394:267-273.
Lee J.-I., Kang, J., Stipanuk, M.H. (2006) Differential regulation of glutamate-cysteine ligase subunit expression and increased holoenzyme formation in response to cysteine deprivation. Biochem. J. 393:181-190.
Stipanuk, M. H., Hirschberger, L. L., Londono, M. P., Cresenzi, C. L., and Yu, A. F. (2004) The ubiquitin-proteasome system is responsible for cysteine-responsive regulation of cysteine dioxygenase concentration in liver. Am. J. Physiol. Endocrinol. Metab. 286: E439-E448.
Lee, J.-I., Londono, M. P., Hirschberger, L. L., and Stipanuk, M. H. (2004) Regulation of cysteine dioxygenase and g-glutamylcysteine synthetase is associated with hepatic cysteine level. J. Nutr. Biochem. 15: 112-122.
Hirschberger, L. L., Daval, S., Stover, P. J., and Stipanuk, M. H. (2000) Murine cysteine dioxygenase: structural organization, tissue-specific expression and promoter identification. Gene 277: 153-161.
Bella, D.L., Hirschberger, L.L., Hosokawa, Y., and Stipanuk, M.H. (1999) The mechanisms involved in the regulation of key enzymes of cysteine metabolism in rat liver in vivo. Am. J. Physiol. 276 (Endocrin. Metab. 39): E326-E335.
Garcia, R.A.G. and Stipanuk, M.H. (1992) The splanchnic organs, liver and kidney have unique roles in the metabolism of sulfur amino acids and their metabolites in rats. J. Nutr. 122: 1693-1701.
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