Anna Thalacker-Mercer

 

Anna Thalacker-Mercer

Assistant Professor
109 Savage Hall
 
Phone: (607) 255-7007
Email: aet74@cornell.edu
View Cornell University Contact Info
 
Biographical Statement:

I graduated from the University of Georgia with a B.S. in Biological Science. I did my graduate training at Purdue University where I received a Ph.D. through the Interdepartmental Nutrition Program in the Department of Nutrition Science (formerly Foods and Nutrition). During my graduate research training I developed a strong background in geriatric nutrition, nutritional genomics, protein metabolism, and the mechanisms of aging skeletal muscle. While analyzing and interpreting the influence of dietary intake on the skeletal muscle transcriptome, I recognized that exercise is necessary for successful health and appreciated the need for training in exercise physiology. Additionally, I developed a keen interest in molecular changes occurring in the skeletal muscle with age, particularly inflammatory and stress responses, which may influence age-related skeletal muscle atrophy (i.e. sarcopenia) and metabolic dysfunction leading to increased adiposity and metabolic disease in older adults. The need for additional training and my developed interests led me to the Center for Exercise Medicine at the University of Alabama at Birmingham (UAB) to study the efficacy of exercise as a therapy for health-related disease and muscle re-growth. I applied to the competitive NIH funded T32 Obesity Training Program and the Center for Aging Translational Research Program at UAB where I completed my postdoctoral fellowship. In December of 2010, I was promoted to Assistant Professor in the UAB Department of Cell, Developmental, and Integrative Biology, with affiliations and support through the UAB Center for Exercise Medicine, the Center for Aging, the Nutrition Obesity Research Center, and the NIH-funded Clinical and Translational Science Award, locally named the Center for Clinical and Translational Science at UAB. During my short time as an Assistant Professor at UAB, I continued to study the mechanisms underlying the observed age-related skeletal muscle phenotypes, and began to appreciate sex differences in aging muscle. Observed differences in the aging female muscle transcriptome sparked my interest in metabolomics and led me to develop collaborations to understand the link between amino acid metabolism and insulin sensitivity. In 2012 I was recruited to the Division of Nutritional Sciences at Cornell University.

My research program is focused on understanding the mechanisms underlying skeletal muscle deterioration and the development of metabolic disease.  

 
Teaching and Advising Statement:

While I take every opportunity to teach and learn from others, I am enthusiastic about formal classroom teaching. I recognize that all students are unique in their learning process and therefore, I incorporate multiple tools to relay course material. Additionally, I am committed to training undergraduate and graduate students and postdoctoral fellows in biomedical science. I believe that hands-on, interactive, goal-oriented research training is the best approach to prepare young investigators for a scientific career. Regular meetings are used to encourage goal development, data interpretation, scientific writing and reading, study design, grantsmanship, and troubleshooting. I strive to keep lines of communication open with my mentees, encouraging them to offer suggestions and new insights to protocols and/or outcomes.

 
Current Professional Activities:
Reviewer: Journals of Gerontology, American Journal of Clinical Nutrition, Journal of Nutrition, Obesity, Nutrition Reviews, Journal of Clinical Endocrinology and Metabolism, Advances in Nutrition, Annals of the New York Academy of Sciences, Journal Frontiers in Exercise Physiology, Journal Frontiers in Skeletal Muscle Physiology

 

 
Current Research Activities:

Characterizing primary human satellite cells; Identifying mechanisms underying impaired muscle regeneration; Using metabolomics to identify and characterize metabolic disturbances underlying the aging skeletal muscle phenotype; Understanding impaired leucine stimulated responses in skeletal muscle health ; Investigating the role of PYY in skeletal muscle myogenesis; Understanding sex differences in the aging skeletal muscle transcriptome; Using metabolomics to identify links between amino acids and peripheral insulin sensitivity; Single-Cell Somatic Mitochondrial DNA Heteroplasmy; Identifying changes in the human, aging male skeletal muscle methylome.

 
Education:

Postdoc 2007-2010 - University of Alabama at Birmingham - Advisor, Marcas Bamman, Ph.D.

Ph.D. 2007 - Nutrition Sciences, Purdue University, Advisor, Wayne Campbell, Ph.D.

B.S. 2000 - Biological Sciences, University of Georgia

 
Courses Taught:

NS6320 Regulation of Macronutrient Metabolism

NS3200 Human Biochemistry

NS3410 Human Anatomy and Physiology

Mentor for graduate student NS7030 presentation

Research mentor for undergraduate research 

Research mentor for graduate research

 
Administrative Responsibilities:

Faculty advisor, Nutrition Graduate Student Organization  

 

 
Selected Publications:

1.    Mentch SJ, Mehrmohamadi M, Huang L, Liu X, Gupta D, Mattocks D, Gómez Padilla P, Ables G, Bamman MM, Thalacker-Mercer AE, Nichenametla SN, Locasale JW. Histone Methylation Dynamics and Gene Regulation Occur through the Sensing of One-Carbon Metabolism. Cell Metab. 2015 Sep 22. pii: S1550-4131(15)00457-X.

2.   Thalacker-Mercer A, Ingram K, Guo F, Newgard C, and Garvey W. Amino Acids and Insulin Sensitivity in Humans: positive correlation between glycine and clamp measures of insulin sensitivity, and negative correlation with leucine/isoleucine, are differentially affected by BMI, RQ, and diabetes. Diabetes. 2014 Feb;63(2):791-800. PMCID: PMC3900549.

3.   Day K, Waite L, Thalacker-Mercer A, West A, Bamman M, Brooks J, Myers R, and Absher D. Differential DNA methylation with age is a result of both common and tissue-specific effects that are influenced by CpG landscape. Genome Biol. 2013 Sep;14(9):R102. PMCID: PMC4053985.

4.   Merritt E, Stec M, Thalacker-Mercer A, Windham S, Cross J, Shelley D, Tuggle S, Kosek D, Kim J, and Bamman, M. Heightened muscle inflammation susceptibility may impair regenerative capacity in aging humans. J Appl Physiol (1985). 2013 Sep;115(6):937-48. PMCID: PMC3764621

5.   Merritt E, Thalacker-Mercer A, Cross J, Windham S, Thomas S, Bamman M. Increased expression of atrogenes and TWEAK family members after severe burn injury in non-burned human skeletal muscle. J Burn Care Res. 2013 Sep-Oct;34(5):e297-304. PMCID: PMC3770758

6.   Thalacker-Mercer A, Stec M, Cui X, Cross J, Windham S, and Bamman M. Cluster analysis reveals differential transcript profiles associated with resistance training-induced human skeletal muscle hypertrophy. Physiol Genomics. 2013 Jun 17;45(12):499-507. PMCID: PMC3680779

7.   Kwak HB, Thalacker-Mercer AE, Anderson EJ, Lin CT, Kane DA, Lee NS, Cortright RN, Bamman MM, and Neufer PD. Simvastatin impairs ADP-stimulated respiration and increases mitochondrial oxidative stress in primary human skeletal myotubes. Free Radic Biol Med. 2011 Oct 25. PMCID: PMC3313473

8.   Thalacker-Mercer AE, Fleet JC, Craig BA, and Campbell WW. The skeletal muscle transcript profile reflects accommodative responses to inadequate protein intake in younger and older males. J Nutr Biochem. 2010 Nov;21(11):1076-82. PMCID: PMC2891367

 

9.    Thalacker-Mercer AE, Dell’Italia LJ, Cui X, Cross JM, and Bamman MM. Differential genomic responses in old vs. young humans despite similar levels of modest muscle damage after resistance loading. Physiological Genomics. Physiol Genomics; 2010 Feb 4;40(3):141-9. PMCID:PMC2825766

 

10.  Thalacker-Mercer AE, Petrella JK, Bamman MM. Does habitual dietary intake influence myofiber hypertrophy in response to resistance training? A cluster analysis. Appl Physiol Nutr Metab. 2009 Aug;34(4):632-9. PMCID:PMC3188961

 

11.  Stull AJ, Iglay HB, Apolzan JW, Thalacker-Mercer AE, and Campbell WW. Liquid and solid meal replacement products differentially affect postprandial appetite and food intake in older humans. J Am Diet Assoc. 2008 Jul;108(7):1226-30. PMCID:PMC2556245

 

12.  Thalacker-Mercer AE, Johnson CA, Yarasheski KE, Carnell NS, Campbell WW. Nutrient ingestion, protein intake, and sex, but not age affect albumin synthesis rate in humans. J Nutr 2007 July; 137 (7): 1734-40. PMCID:PMC3885871

 

13.  Thalacker-Mercer AE, Fleet JC, Craig BA, Carnell NS, Campbell WW. Inadequate protein intake affects skeletal muscle transcript profiles in older humans. Am J Clin Nutr 2007 May; 85(5):1344-52. PMCID:PMC2447912

Chapters, Reviews, and Proceedings Articles (*corresponding author)

1.    1.      Gheller BJ, Riddle ES, Lem MR, *Thalacker-Mercer A. Understanding age-related changes in skeletal muscle metabolism: differences between females and males. Annu Rev Nutr. 2016 Jul 17;36:129-56.

 Riddle E, Stipanuk M, and *Thalacker-Mercer A. Amino Acids in Healthy Aging Skeletal Muscle. Front Biosci (Elite Ed). 2016 Jan 1;8:326-50.

2.    *Thalacker-Mercer AE and Drummond MJ. Protein metabolism in inactive older adults. New York Academy of Sciences. Ann N Y Acad Sci. 2014 Aug 12

3.   Guoyao Wu, Jessica Fanzo, Dennis D. Miller, Prabhu Pingali, Mark Post, Jean L. Steiner, and Anna E. Thalacker-Mercer. Production and supply of high-quality food protein for human consumption: sustainability, challenge and innovations. NYAS Annals Meeting Reports. Ann N Y Acad Sci. 2014 Aug;1321(1):1-19

4.   Krista Casazza, Lynae J. Hanks, Anna Thalacker-Mercer. Insulin-like growth factor system in different ethnic groups and relationship with growth and health. The Handbook of Growth and Growth Monitoring in Health and Disease. 

5.   Thalacker-Mercer AE, and Campbell WW. Dietary protein intake affects albumin fractional synthesis rate equally in younger and older adults.  Nutr Rev. 2008 Feb;66(2):91-5

6.   Campbell, WW, Carnell, NS, and Thalacker, AE.  Protein Metabolism and Requirements.  Geriatric Nutrition; The Health Professional’s Handbook. 3rd Ed. 2006 p15-22

Web-based Peer-Reviewed Publications (*corresponding author)

1.   *Thalacker-Mercer AE. Counterbalancing Functional Deficits from Acute Illness Hospitalization. The Deep South CME Network, UAB Geriatric Education Center, UAB Division of CME. www.alabamacme.uab.edu/geriatrics.aspx. May 2012. 

 

2.   Herrington HL, Lawrence JC, Ponder A, Thalacker-Mercer AE, Willis AS, McLinn J. eight Management in Older Adults. The Deep South CME Network, UAB Geriatric Education Center, UAB Division of CME. www.alabamacme.uab.edu/geriatrics.aspx. November 2012.

 
Selected Keywords:
satellite cell, sarcopenia, aging, skeletal muscle, metabolism, inflammation, metabolic dysfunction, protein, amino acids

 
The information on this bio page is taken from the CHE Annual Report.